855261-19-7Relevant academic research and scientific papers
Ortho-lithium/magnesium carboxylate-driven aromatic nucleophilic substitution reactions on unprotected naphthoic acids
Aissaoui, Regadia,Nourry, Arnaud,Coquel, Ariane,Dao, Thi Thanh Ha,Derdour, Aicha,Helesbeux, Jean-Jacques,Duval, Olivier,Castanet, Anne-Sophie,Mortier, Jacques
, p. 718 - 724 (2012)
Substitution of an ortho-fluoro or methoxy group in 1- and 2-naphthoic acids furnishing substituted naphthoic acids occurs in good to excellent yields upon reaction with alkyl/vinyl/aryl organolithium and Grignard reagents, in the absence of a metal catalyst without the need to protect the carboxyl (CO 2H) group. This novel nucleophilic aromatic substitution is presumed to proceed via a precoordination of the organometallic with the substrate, followed by an addition/elimination.
