855296-66-1Relevant academic research and scientific papers
Synthesis and study of some new N-substituted imide derivatives as potential anticancer agents
Jindal, Dharam Paul,Bedi, Vikas,Jit, Birinder,Karkra, Nalin,Guleria, Sheetal,Bansal, Ranju,Palusczak, Anja,Hartmann, Rolf W.
, p. 283 - 290 (2007/10/03)
A new series of N-substituted imide derivatives have been synthesized by treating phthalic anhydride, naphthalic anhydride and their substituted derivatives with 2-hydrazino-1-imidazoline hydrobromide, various para-substituted aryl amines, aminoglutethimide and 2,4-dinitrophenyl hydrazine. Compounds 9, 10, 12, 18, 19, 23, 24 and 34-36 have been selected and screened for antineoplastic activity by National Cancer Institute, Bethesda, USA. Some newer aminoglutethimide derivatives 37-39 have also been prepared in order to study the effect of N-substitution on its pharmacological profile for the treatment of carcinoma. These compounds (37-39) have exhibited weak inhibition of human placental aromatase as compared to aminoglutethimide.
