855299-80-8Relevant academic research and scientific papers
A novel class of in vivo active anticancer agents: Achiral seco-amino- and seco-hydroxycyclopropylbenz[e]indolone (seco-CBI) analogues of the duocarmycins and CC-1065
Sato, Atsushi,McNulty, LuAnne,Cox, Kari,Kim, Susan,Scott, Adrienne,Daniell, Kristen,Summerville, Kaitlin,Price, Carly,Hudson, Stephen,Kiakos, Konstantinos,Hartley, John A.,Asao, Tetsuji,Lee, Moses
, p. 3903 - 3918 (2007/10/03)
One achiral seco-hydroxycyclopropylbenz[e]indolone (seco-CBI) (12) and seven achiral seco-amino-CBI (11a-g) analogues of CC-1065 and the duocarmycins were designed, synthesized and evaluated for their DNA-binding and anticancer properties. These compounds
