855303-07-0Relevant academic research and scientific papers
Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer
Takahashi, Takashi,Nakai, Kazuoki,Doi, Takayuki,Yasunaga, Masa,Nakagawa, Hiroshi,Ishikawa, Toshihisa
, p. 2601 - 2605 (2005)
We have developed a practical synthetic route to construct C-aromatic taxane derivatives as three-dimension templates by way of intramolecular alkylation. The usefulness of synthesized compounds as the core template was evaluated by using a newly developed screening system for P-glycoprotein.
