855316-62-0

Basic information

• Product Name: 3-(R)-methyl-1-[2-oxo-3-(R)-(3,4-difluorophenyl)tetrahydro-2H-pyran-4(R)-ylmethyl]piperidine-3-carboxylic acid ethyl ester
• Synonyms: 3-(R)-methyl-1-[2-oxo-3-(R)-(3,4-difluorophenyl)tetrahydro-2H-pyran-4(R)-ylmethyl]piperidine-3-carboxylic acid ethyl ester
• CAS NO: 855316-62-0
• Molecular Weight: 395.446
• Mol File: 855316-62-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(R)-methyl-1-[2-oxo-3-(R)-(3,4-difluorophenyl)tetrahydro-2H-pyran-4(R)-ylmethyl]piperidine-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(R)-methyl-1-[2-oxo-3-(R)-(3,4-difluorophenyl)tetrahydro-2H-pyran-4(R)-ylmethyl]piperidine-3-carboxylic acid ethyl ester(855316-62-0)
• EPA Substance Registry System: 3-(R)-methyl-1-[2-oxo-3-(R)-(3,4-difluorophenyl)tetrahydro-2H-pyran-4(R)-ylmethyl]piperidine-3-carboxylic acid ethyl ester(855316-62-0)

Safety Data

• Hazardous Substances Data: 855316-62-0(Hazardous Substances Data)

Upstream product

• 440370-30-9 (1R,2R)-2-(3,4-difluorophenyl)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl acetamide 
• 440370-39-8 (E)-1-(3-ethoxycarbonylallyl)-3-(R)-methylpiperidine-3-carboxylic acid ethyl ester 
• 658-93-5 (3,4-difluorophenyl)acetic acid 

Downstream Products

• 855316-64-2 1-[3-(R)-(3,4-difluorophenyl)-2-(4-nitrobenzoyloxy)tetrahydro-2H-pyran-4(R)-ylmethyl]-3-(R)-methylpiperidine-3-carboxylic acid ethyl ester 
• 855316-63-1 1-[3-(R)-(3,4-difluorophenyl)-2-hydroxytetrahydro-2H-pyran-4(R)-ylmethyl]-3-(R)-methylpiperidine-3-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis of a tetrahydropyran NK1 receptor antagonist via asymmetric conjugate addition

Two asymmetric syntheses of the NK1 receptor antagonist 1-[2-(R)-{1-(R)-[3,5-bis(trifluoromethyl)-phenyl]ethoxy}-3-(R)-(3, 4-difluorophenyl)-4-(R)-tetrahydro-2H-pyran-4-ylmethyl]-3-(R) -methylpiperidine-3-carboxylic acid (1) were developed. In