855348-18-4

Upstream product

• 229-87-8 phenanthridine 
• 106-42-3 para-xylene 
• 622-47-9 4-tolylacetic acid 
• 2947-61-7 (4-methylphenyl)acetonitrile 
• 591-50-4 iodobenzene 
• 3128-77-6 2-isocyanobiphenyl 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 90-41-5 2-phenylaniline 

Relevant academic research and scientific papers

Aerobic cross-dehydrogenative couplings of N-heteroarenes with toluene derivatives at room temperature

A set of mild aerobic cross-dehydrogenative couplings of N-heteroarenes with the benzylic C(sp3)-H bond has been achieved by using visible-light-induced photocatalysis. This approach was found to provide a sustainable alternative to Minisci benzylation reactions using readily accessible toluene derivatives as benzylating agents. The unique combination of photocatalysis, bromo radical mediation, and aerobic oxidation proved to be the key for the success of the transformation. Mechanistic studies revealed the feasibility of both oxidative and reductive quenching of the excited photocatalyst in the initial step.

Visible-Light-Initiated, Photocatalyst-Free Decarboxylative Coupling of Carboxylic Acids with N-Heterocycles

A general and efficient protocol for direct C-H alkylation and acylation of N-heterocycles, using readily accessible carboxylic acids as radical precursors under visible-light irradiation without a photocatalyst and an additional acid additive, has been d

Rapid synthesis of polysubstituted phenanthridines from simple aliphatic/aromatic nitriles and iodo arenes: Via Pd(ii) catalyzed domino C-C/C-C/C-N bond formation

An efficient and straightforward method has been developed for the synthesis of polysubstituted phenanthridines from simple aryl iodides and alkyl/aryl nitriles via the palladium-catalyzed nucleophilic addition of aryl iodides to nitriles followed by casc

Synthetic method of 6-benzyl phenanthridine compounds

The invention discloses a synthetic method of 6-benzyl phenanthridine compounds. A reaction equation is as follows: formula (shown in the description), wherein R represents hydrogen, fluorine, chlorine, methyl, methoxyl or a naphthalene ring. The synthetic method has the beneficial effects that (1) the operation of the preparation process is simple and convenient, and the post-treatment of obtained products is easy; (2) high temperature and high pressure conditions are not required, and reaction conditions are mild; (3) a catalyst is not required, and the synthetic cost is lowered; (4) functional groups of a reaction substrate are high in tolerance, and the substrate is wide in range and easy to prepare; (5) an oxidant is cheap, easily available and relatively economic; (6) the reaction is efficient and high in yield; and (7) the synthetic method is pollution-free and environment-friendly.

Free-amine-directed alkenylation of C(sp2)-H and cycloamination by palladium catalysis

A new protocol for the palladium-catalyzed free-amine-directed alkenylation of C(sp2)-H bonds and cycloamination is described. Substituted biaryl-2-amines react with various alkenes, including electron-deficient alkenes, aryl alkenes and alkyl alkenes, to give the corresponding phenanthridines with exclusive regioselectivity. The use of α-branched styrenes leads to the formation of tricyclic compounds with a seven-membered amine ring. The method operates through a free-amine-directed alkenylation and a subsequent hydroamination cyclization reaction. Seven-membered cycloamination: A new protocol for the palladium-catalyzed free-amine-directed alkenylation of C(sp2)-H bonds and subsequent cycloamination is described (see scheme). Substituted biaryl-2-amines react with various alkenes to give the corresponding phenanthridines with exclusive regioselectivity. The use of α-branched styrenes leads to the formation of tricyclic compounds with a seven-membered amine ring. Copyright