85535-54-2Relevant academic research and scientific papers
Synthesis of protected 3-aminopiperidine and 3-aminoazepane derivatives using enzyme cascades
Baldwin, Christopher R.,Birmingham, William R.,Flitsch, Sabine L.,Ford, Grayson J.,Hepworth, Lorna J.,Huang, Min,Kress, Nico,Marshall, James R.,Mattey, Ashley P.,Seibt, Lisa S.,Turner, Nicholas J.
supporting information, p. 7949 - 7952 (2020/09/09)
Multi-enzyme cascades utilising variants of galactose oxidase and imine reductase led to the successful conversion of N-Cbz-protected l-ornithinol and l-lysinol to l-3-N-Cbz-aminopiperidine and l-3-N-Cbz-aminoazepane respectively, in up to 54% isolated yi
Exploration of the P1 SAR of aldehyde cathepsin K inhibitors.
Catalano, John G,Deaton, David N,Furfine, Eric S,Hassell, Annie M,McFadyen, Robert B,Miller, Aaron B,Miller, Larry R,Shewchuk, Lisa M,Willard Jr., Derril H,Wright, Lois L
, p. 275 - 278 (2007/10/03)
The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S(1) subsite with a series of alpha-amino aldehyde derivatives substituted at the P(1) position afforded compounds with cathepsin K IC(50)s between 52 microM and 15 nM.
