85535-56-4

Basic information

• Product Name: tert-Butyl (6-aMino-6-oxohexyl)carbaMate
• Synonyms: tert-Butyl (6-aMino-6-oxohexyl)carbaMate
• CAS NO: 85535-56-4
• Molecular Formula: C₁₁H₂₂N₂O₃
• Molecular Weight: 230.30398
• Mol File: 85535-56-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: tert-Butyl (6-aMino-6-oxohexyl)carbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl (6-aMino-6-oxohexyl)carbaMate(85535-56-4)
• EPA Substance Registry System: tert-Butyl (6-aMino-6-oxohexyl)carbaMate(85535-56-4)

Safety Data

• Hazardous Substances Data: 85535-56-4(Hazardous Substances Data)

Usage

General Description

The chemical tert-Butyl (6-aMino-6-oxohexyl)carbaMate is a carbamate derivative compound that consists of a tert-butyl group attached to a six-carbon chain with an amino and oxo functional group. tert-Butyl (6-aMino-6-oxohexyl)carbaMate is mainly used in pharmaceutical and chemical research as an intermediate for the synthesis of various drugs and pharmaceuticals. It has the potential to act as a precursor for the production of neuroprotective and neuroregenerative drugs due to its structural properties. Additionally, it may also have applications in the field of agriculture as a potential pesticide or herbicide. However, further research and testing are necessary to fully understand its potential uses and effects.

Upstream product

• 6404-29-1 6-(tert-butoxycarbonylamino)hexanoic acid 

Downstream Products

• 51857-17-1 tert-butyl N-(6-aminohexyl)carbamate 
• 118110-05-7 tert-butyl (5-cyanopentyl)carbamate 

Relevant articles and documents

The structure-activity profile of mercaptobenzamides’ anti-HIV activity suggests that thermodynamics of metabolism is more important than binding affinity to the target

Mercaptobenzamide thioesters and thioethers are chemically simple HIV-1 maturation inhibitors with a unique mechanism of action, low toxicity, and a high barrier to viral resistance. A structure-activity relationship (SAR) profile based on 39 mercaptobenzamide prodrug analogs exposed divergent activity/toxicity roles for the internal and terminal amides. To probe the relationship between antiviral activity and toxicity, we generated an improved computational model for the binding of mercaptobenzamide thioesters (SAMTs) to the HIV-1 NCp7 C-terminal zinc finger, revealing the presence of a second low-energy binding orientation, hitherto undisclosed. Finally, using NMR-derived thiol–thioester exchange equilibrium constants, we propose that thermodynamics plays a role in determining the antiviral activity observed in the SAR profile.

A Convenient and General Method for the Preparation of tert-Butoxycarbonylaminoalkanenitriles and Their Conversion to Mono-tert-butoxycarbonylalkanediamines

A new method is described for the synthesis of tert-butoxycarbonylaminoalkanenitriles 3 by dehydration of the corresponding carboxamides 2 (prepared in two steps from aminoalkanoic acids) in the presence of trifluoroacetic anhydride and triethylamine.N-Boc-aminoalkanenitriles 3 are easily converted to mono-N-Boc-alkanediamines 4 under mild conditions avoiding the cleavage of the N-protective group.The monoprotected alkanediamines 4 are useful tools in affinity chromatography.