85539-83-9

Usage

Uses

p-Xyleneselenocyanate is a synthetic organoselenium chemopreventive agent.

InChI:InChI=1/C10H8N2Se2/c11-7-13-5-9-1-2-10(4-3-9)6-14-8-12/h1-4H,5-6H2

Upstream product

• 623-24-5 1,4-bis(bromomethyl)benzene 
• 3425-46-5 potassium selenocyanate 

Downstream Products

• 116072-83-4 C₂₀H₁₈Se₂ 
• 1171874-32-0 1,4-bis{[(trimethylsilyl)ethynylselenyl]methyl}benzene 

Relevant academic research and scientific papers

Halide ion recognition: Via chalcogen bonding in the solid state and in solution. Directionality and linearity

Group 16 chalcogen atoms may exhibit Lewis acidic σ-holes which are able to form attractive supramolecular interactions with Lewis bases via chalcogen bonds (ChB). Interest in ChB is increasing rapidly; however, the potential for anion binding has not been fully explored. Herein we report on the application of chemically robust and stable benzylic selenocynates (1 and 2) for halide ion recognition in the solid state and in solution. Single crystal X-ray structural analysis of various cocrystals reveals structurally important Se?X- (X = Cl, Br, I) chalcogen bonds. Changes in the 13C and 77Se chemical shifts via NMR spectroscopy show how halide ion recognition influences the local electronic environment of the selenium atoms in solution. Deviations of the interaction from the extension of the C-Se covalent bond are quantified and assessed with the aid of computational chemistry.

Solvent free nucleophilic selenocyanation with [bmim][SeCN]. Direct access to perfluoroalkylselenide compounds

Available online-1-n-butyl-3-methylimidazolium selenocyanate ([bmim][SeCN]) proved to be a very efficient reagent for selenocyanation of alkyl halides. As part of an eco-friendly process, no organic solvents were used during the transformation and reaction times are reduced by using microwave as a heating source. The ionic liquid was carefully recycled in two different ways. Selenocyanate compounds were successfully transformed into trifluoromethylselenides in a one-pot two step procedure.

Direct investigation of chalcogen bonds by multinuclear solid-state magnetic resonance and vibrational spectroscopy

We report a multifaceted experimental and computational study of three self-complementary chalcogen-bond donors as well as a series of seven chalcogen bonded cocrystals. Bis(selenocyanatomethyl)benzene derivatives were cocrystallized with various halide s

Potent anti-proliferative activities of organochalcogenocyanates towards breast cancer

The pharmacological importance, particularly the anti-cancer and chemopreventive potentials, of organochalcogen compounds has attracted wide research attention recently. Herein we describe the synthesis of a series of organochalcogenocyanates that have one or more selenocyanate or thiocyanate units in a single molecule. The anti-proliferative activity of these organochalcogenocyanates in different breast cancer cells shows that selenocyanates exhibit much higher anti-proliferative activities than thiocyanates in general. Our study reveals that the activity of benzyl selenocyanate (1, BSC) could be significantly enhanced by 4-nitro substitution (12), which was more selective towards triple-negative breast cancer cells (MDA-MB-231) over other ER+ breast cancer cells (MCF-7 and T-47D). Furthermore, to the best of our knowledge, this is the first report on the synthesis of compounds having more than two selenocyanate units with promising anti-proliferative activities. Our studies further indicate that the apoptotic activities of selenocyanates are associated with modulation of cellular morphology and cell cycle arrest at S-phase. Selenocyanates also inhibited cellular migration and exhibited weak antioxidant activities. An effective binding interaction of compound 12 with serum albumin indicates its feasible transport in the bloodstream for its enhanced anti-cancer properties. Mechanistic studies by western blot analysis demonstrate that benzylic selenocyanates exhibit anti-proliferative activities by modulating key cellular proteins such as Survivin, Bcl-2 and COX-2; this was further supported by molecular docking studies. The results of this study would be helpful in designing suitable chemotherapeutic and chemopreventive drugs in the future.

Organic selenocyanates as strong and directional chalcogen bond donors for crystal engineering

Organic bis(selenocyanate) derivatives act as powerful chalcogen bond donors for the elaboration of 1D extended structures upon co-crystallization with 4,4′-bipyridine as a ditopic chalcogen bond acceptor.

Supramolecular organization based on van der Waals forces: Syntheses and solid state structures of isomeric [6.6] cyclophanes with 2,5-diselenahex-3-yne bridges

The ortho, meta,and para isomers 4-6 of [6.6]cyclophanes with 2,5-diselenahex-3-yne bridges were synthesized by reacting the bis(selenocyanatomethyl)benzene derivatives 8a- 8c with the lithium salt of trimethylsilylethyne to yield 9a-9c, deprotection of w

Synthesis and Multinuclear NMR Characterizations of Some Diselena- and Tetraselenacyclophanes.

Several symmetrical and unsymmetrical bis-selenacyclophanes were prepared and characterized by multinuclear (1H, 13C and 77Se) NMR.The symmetrical cyclophanes of phenyl, furyl, pyridyl and thiophenyl appear to exist in predominantly syn conformation in solution at room temperature.VT-1H NMR of some cyclophanes indicate that the equilibrium between the syn conformers which differ in the disposition of the bridge seleniums (symmetric about mirror plane symmetric about inversion center) can be slowed at low temperatures.Interesting 13C shifts are observed in unsymmetrical cyclophanes containing 2,2'-biphenyl, pyridine and furan.The 77Se chemical shifts appear to be related to the size of the cavity of the cyclophanes.