85541-12-4Relevant academic research and scientific papers
Inhibition of peptidylglycine α-amidating monooxygenase by N-substituted homocysteine analogs
Erion,Tan,Wong,Jeng
, p. 4430 - 4437 (2007/10/02)
C-terminal amidation is a posttranslational modification found in many neuropeptides. Peptidylglycine α-amidating monooxygenase (PAM) catalyzes the synthesis of the biologically essential C-terminal amide from a glycine- extended precursor peptide. Report
Selectivity in the Trimethylsilylation and Acylation of Peptide Bonds, and its Application to Modification of the Enkephalins
Davies, John S.,Merritt, Raymond K.,Treadgold, Richard C.,Morley, John S.
, p. 2939 - 2948 (2007/10/02)
N.m.r. spectra of N-acylated peptides, formed by reaction of protected peptides with silylating agents followed by acylation, have provided a means for assessing selectivity in the acylation of amide bonds.Amino-acids such as valine and phenylalanine prev
