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Usage

Uses

Used in Pharmaceutical Industry:
(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ANHYDRIDE is used as a reagent for the synthesis of various drugs and pharmaceutical intermediates. Its unique structure allows for the creation of a broad range of medicinal compounds, contributing to the development of new treatments and therapies.
Used in Research Laboratories:
In research settings, (+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ANHYDRIDE is employed for the preparation of other organic compounds. Its versatility in chemical reactions makes it a valuable tool for scientists exploring new chemical pathways and syntheses.
Used as a Precursor in Asymmetric Synthesis:
(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ANHYDRIDE also serves as a precursor in the synthesis of chiral auxiliaries and catalysts, which are essential in asymmetric synthesis. This application is crucial for producing enantiomerically pure compounds, a key aspect in the development of many pharmaceuticals and agrochemicals.
Safety Considerations:
It is important to handle (+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ANHYDRIDE with care, as it may pose hazards if not properly managed. Adequate safety measures should be taken to ensure the well-being of individuals working with (+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ANHYDRIDE.

Upstream product

• 20445-31-2 R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid 

Downstream Products

• 1020084-75-6 (3R,4S)-4-[allyl(tert-butoxycarbonyl)amino]pent-1-en-3-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate 

Relevant academic research and scientific papers

New building block for polyhydroxylated piperidine: Total synthesis of 1,6-dideoxynojirimycin

(Chemical Equation Presented) (3R,4S)-3-Hydroxy-4-N-allyl-N-Boc-amino-1- pentene 10, an important precursor for the synthesis of polyhydroxylated piperidines, has been achieved as a single diastereomer without racemization via vinyl Grignard addition to N-Boc-N-allyl aminoaldehyde 9, which was derived from an enantiopure natural amino acid. Having forged a tetrahydropyridine ring scaffold 13 from 10 in 85% yield via RCM using Grubbs II catalyst, we were able to effect its stereodivergent dihydroxylation, via a common epoxide intermediate to yield a range of interesting hydroxylated piperidines, including ent-1,6-dideoxynojirimycin (ent-1,6-dDNJ) 1 (28% overall yield) and 5-amino-1,5,6-trideoxyaltrose 2 (29% over all yield) in excellent dr. To the best of our knowledge, our synthesis of ent-1,6-dDNJ 1 is the most expeditious to date.

Improved stereoselectivity in intramolecular SN2′ cyclization through use of mechanistic principles

Valine and alanine were converted into the corresponding α-hydroxy-β-amino acids through intramolecular SN2′ cyclization. The novel cyclization protocol relied upon the use of N-benzyl-protected carbamates derived from α-amino acids. Georg Thie

Total synthesis of amamistatin A, an antiproliferative linear peptide from an actinomycete

Amamistatin A, a linear lipopeptide and a growth inhibitor of human tumor cell lines from an actinomycete, was efficiently synthesized by a convergent approach. The asymmetric synthesis of β-hydroxy acid fragment was achieved by using chiral oxazaborolidinone mediated aldol reaction. The oxazole ring was constructed from N-acylthreonine via side-chain oxidation and cyclodehydration. The synthesis of the linear peptide was carded out in a stepwise manner from the cyclic hydroxamic acid fragment, and the final deprotection provided amamistatin A. (C) 2000 Elsevier Science Ltd.