855418-85-8

Upstream product

• 1873-55-8 3-methylquinoline N-oxide 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 90-02-8 salicylaldehyde 
• 123-38-6 propionaldehyde 
• 62-53-3 aniline 
• 5344-90-1 2-Aminobenzyl alcohol 
• 1467-39-6 1-(2-hydroxyphenyl)-2-propen-1-one 
• 91-56-5 indole-2,3-dione 
• 854871-27-5 2-(2-hydroxy-phenyl)-3-methyl-quinoline-4-carboxylic acid 

Relevant academic research and scientific papers

Iridium-Catalyzed Transfer Hydrogenation for Construction of Quinolines from 2-Aminobenzyl Alcohols with Enones in Water

Herein, we describe a method for the synthesis of functionalized quinolines from 2-aminobenzyl alcohols with -nsaturatedketones.This method exhibits tolerance to various functional groups and high efficiency, is environmentally benign, and can be performed on a gram scale. Control experiments suggest that this transformation is accomplished by iridium complex catalyzed transfer hydrogenation, which is then followed by Friedl nder cyclization. The results display that alkali is essential for the high selectivities of this catalytic system.

One-pot synthesis of quinoline derivatives using choline chloride/tin (II) chloride deep eutectic solvent as a green catalyst

In this work, various quinoline derivatives were prepared efficiently through a one-pot, three component synthesis using choline chloride/tin(II) chloride (ChCl·2SnCl2) deep eutectic solvent (DES) as a green catalyst. The procedure is free of using toxic solvents or catalyst and it could be categorized as a green method. In this procedure, aniline derivatives, aromatic aldehydes and enolizable aldehydes were mixed in the presence of DES that plays both roles of solvent and the reaction catalyst. Using this methodology, quinoline derivatives were synthesized simply at 60 °C in 2-3 h with high yields (54-97%). All products were purified by chromatography and recrystallization in ethanol. The employed DES have been recycled 4 time without important loss of its activity.

Novel formation of oxazepino[4,5-a]quinolines by tandem 1,3-dipolar and insertion reaction of quinoline N-oxides with arynes

By combination of 1,3-dipolar cycloaddition and N-O single bond insertion, tandem synthesis of dibenzo[1,4]-oxazepino[4,5-a]quinolines was accomplished. Reaction of quinoline N-oxides with arynes afforded 2-(2-hydroxyphenyl) quinolines and 7-membered pentacyclic oxazepino[4,5-a]quinolines.