855482-81-4 Usage
Uses
Used in Organic Synthesis:
[3-isobutyl-4-(methoxycarbonyl)phenyl]boronic acid is used as a reagent in organic synthesis for the creation of complex molecular structures. Its unique functional groups facilitate a range of chemical reactions, making it a versatile component in the synthesis of various compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, [3-isobutyl-4-(methoxycarbonyl)phenyl]boronic acid is used as a key intermediate in the development of new drugs. Its ability to selectively bind to certain biomolecules makes it a useful tool in drug discovery, potentially leading to the creation of more effective and targeted medications.
Used in Suzuki-Miyaura Coupling Reactions:
[3-isobutyl-4-(methoxycarbonyl)phenyl]boronic acid is employed as a reagent in Suzuki-Miyaura coupling reactions, which are widely used in the synthesis of biaryl compounds. These reactions are crucial for the production of various pharmaceuticals, agrochemicals, and advanced materials, highlighting the compound's importance in the field of chemical research and development.
Used in Chemical Biology Research:
[3-isobutyl-4-(methoxycarbonyl)phenyl]boronic acid's boronic acid functionality allows for selective binding to certain biomolecules, making [3-isobutyl-4-(methoxycarbonyl)phenyl]boronic acid a valuable tool in chemical biology research. This selective binding can be utilized to study the interactions between biomolecules and develop new strategies for targeting specific biological processes or pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 855482-81-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,5,4,8 and 2 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 855482-81:
(8*8)+(7*5)+(6*5)+(5*4)+(4*8)+(3*2)+(2*8)+(1*1)=204
204 % 10 = 4
So 855482-81-4 is a valid CAS Registry Number.
855482-81-4Relevant academic research and scientific papers
Discovery of a novel series of biphenyl benzoic acid derivatives as potent and selective human β3-adrenergic receptor agonists with good oral bioavailability. Part I
Imanishi, Masashi,Tomishima, Yasuyo,Itou, Shinji,Hamashima, Hitoshi,Nakajima, Yutaka,Washizuka, Kenichi,Sakurai, Minoru,Matsui, Shigeo,Imamura, Emiko,Ueshima, Koji,Yamamoto, Takao,Yamamoto, Nobuhiro,Ishikawa, Hirofumi,Nakano, Keiko,Unami, Naoko,Hamada, Kaori,Matsumura, Yasuhiro,Takamura, Fujiko,Hattori, Kouji
, p. 1925 - 1944 (2008/12/20)
A novel class of biphenyl analogues containing a benzoic acid moiety based on lead compound 8i have been identified as potent and selective human β3 adrenergic receptor (β3-AR) agonists with good oral bioavailability and long plasma half-life. After further substituent effects were investigated at the terminal phenyl ring of lead compound 8i, we have discovered that more lipophilic substitution at the R position improved potency and selectivity. As a result of these studies, 10a and 10e were identified as the leading candidates with the best balance of potency, selectivity, and pharmacokinetic profiles. In addition, compounds 10a and 10e were evaluated to be efficacious for a carbachol-induced increase of intravesical pressure, such as an overactive bladder model in anesthetized dogs. This represents the first demonstrated result dealing with β3- AR agonists.
