855517-79-2

Upstream product

• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 81658-27-7 (S)-tert-butyl 2-(((tert-butyldimethylsilyl)oxy)methyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 855517-77-0 (2S,3R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 5437-45-6 Benzyl bromoacetate 
• 855517-78-1 (3S,4R,5S)-3-benzyloxycarbonylmethyl-5-(tert-butyldimethyl-silanyloxymethyl)-4-(4-methoxy-phenyl)-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 855517-80-5 (2S,3R,4R)-4-benzyloxycarbonylmethyl-3-(4-methoxy-phenyl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 855517-81-6 (2S,3R,4R)-4-carboxymethyl-3-(4-methoxyphenyl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 

Relevant academic research and scientific papers

Stereoselective synthesis of new modified conformationally constrained L-tyrosine analogue with potential applications to SH2 domain ligands

This paper reports the stereoselective synthesis of a modified tricyclic tyrosine analogue 3, whose conformation is constrained by the covalent bonds and designed on the basis of X-ray and solution structures of SH2 domain and its natural peptide ligand.