855636-38-3

Usage

Uses

Used in Pharmaceutical Industry:
2-ForMylisonicotinic acid is used as an intermediate in the synthesis of anti-tuberculosis and anti-inflammatory drugs for its ability to contribute to the development of effective medications that address these health concerns.
Used in Agrochemical Industry:
2-ForMylisonicotinic acid is used as a building block in the production of herbicides and insecticides, enabling the creation of agricultural chemicals that protect crops from pests and enhance crop yields.
Used in Organic Synthesis:
2-ForMylisonicotinic acid is used as a versatile building block in organic synthesis for its ability to be incorporated into a wide range of organic compounds, contributing to the advancement of chemical research and development in various industries.

Upstream product

• 4021-11-8 2-methylisonicotinic acid 
• 1211520-08-9 2-vinyl-isonicotinic acid 

Downstream Products

• 1429329-82-7 5-(2-(4-fluorophenyl)thiazol-5-yl)-5,6,7,8-tetrahydroisoquinolin-5-ol 

Relevant academic research and scientific papers

Iron-catalyzed oxidative C-C(vinyl) σ-bond cleavage of allylarenes to aryl aldehydes at room temperature with ambient air

A general and selective iron-catalyzed allylic C-C(vinyl) σ-bond cleavage of allylarenes without the assistance of heteroatoms to give aryl aldehydes is reported. The unstrained carbon-carbon single bond cleavage reaction uses ambient air as the sole oxidant, proceeds efficiently at room temperature, and allows for exceptional functional-group tolerance, which addresses the long-standing challenges of current C-C bond cleavage/functionalization. Notably, the method enables rapid late-stage oxidation of complex bioactive molecules and can be used to expedite syntheses of natural products (vanillin and glucovanillin) from readily available chemical feedstocks.

A 2 - [...] preparation of nicotinic acid

The invention discloses a 2 - [...] method for preparing nicotinic acid, which belongs to the field of organic chemical synthesis. The method is to 2 - methyl isobutyl ketone nicotinic acid as the raw material, in the iodine in dimethyl sulfoxide by heating the mixed system for directly preparing the product 2 - [...] of nicotinic acid. The invention discloses a 2 - [...] nicotinic acid preparation method is simple, easy to operate, simple and easy to obtain raw materials and reagents, yield and high purity, it is suitable for industrial production and application, the material as an important organic synthetic intermediates, can be applied to the Schiff base and anti-tumor pharmaceutical preparation, there are broad medical application prospect.

Synthesis method of 2-formyl group-4-picolinic acid

The invention discloses a synthesis method of 2-formyl group-4-picolinic acid and belongs to the field of organic synthesis. In the method, 2-formyl group-4-picolinic acid is taken as a raw material,an organic solvent is taken as a reactive solvent, selenium dioxide is taken as a reaction reagent, and 2-formyl group-4-picolinic acid is obtained directly by heating. The synthesis method is conciseand efficient, low in cost, convenient in operation, easy to control and easy for industrialized production.

4-HETEROARYLMETHYL SUBSTITUTED PHTHALAZINONE DERIVATIVES

A compound of formula (I): for use in treating cancer or other diseases ameliorated by the inhibition of PARP, wherein: A and B together represent an optionally substituted, fused aromatic ring; X can be NRx or CRxRy; if X=NRx then n is 1 or 2 and if X=CRxRy then n is 1; Rx is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; Ry is selected from H, hydroxy, amino; or Rx and Ry may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are independently selected from the group consisting of hydrogen and C1-4 alkyl, or when X is CRxRy, RC1, RC2, Rx and Ry, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; R1 is selected from H and halo; and Het is selected from: (i) formula (i), where Y1 is selected from CH and N, Y2 is selected from CH and N, Y3 is selected from CH, CF and N, where only one or two of Y1, Y2 and Y3 can be N; and (ii) formula (ii), where Q is O or S.