855660-91-2Relevant academic research and scientific papers
Biocatalytic aminolysis of ethyl (S)-mandelate by lipase from Candida antarctica
Lima, Rafaely N.,Porto, André L.M.
, p. 157 - 163 (2017/07/12)
Enzymes play many roles in the advancement of biotechnology, discovery of new therapeutic agents and industrial processes. In this perspective, aminolysis reactions using lipase from Candida antarctica (CAL-B) were performed from ethyl (S)-mandelate and several aliphatic amines (45 °C, hexane, 3–6 h). By means of optimized conditions, amides with excellent isolated yields (60–97%) were synthetized. The biotechnological potential of CAL-B as a promising approach for the synthesis of organic compounds in a more sustainable, rapid, efficient and green chemistry perspective was verified on these results.
A two-step chemical/chiroptical method for determining absolute configurations of α-hydroxy acids
Rickman, Barry H.,Matile, Stefan,Nakanishi, Koji,Berova, Nina
, p. 5041 - 5064 (2007/10/03)
A general, chemical/chiroptical approach based on the CD exciton chirality method has been developed to determine the absolute configuration of α-hydroxy acids. This approach consists of amidation of the carboxyl group with ethanolamine followed by deriva
