85573-11-1

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 635-93-8 5-chlorosalicyclaldehyde 

Downstream Products

• 41433-12-9 2-(2'-Hydroxy-5'-chlorophenyl)benzimidazole 
• 1319716-53-4 [C₆H₄(NCHC₆H₃OCl)2Ti(OC₆H₃(CH₃)2)2] 

Relevant academic research and scientific papers

Synthesis, characterization, X-ray diffraction studies and biological properties of Ni(II) and Pd(II) complexes of tetradentate schiff bases

Ni(II) and Pd(II) complexes of ONNO type tetradentate Schiff bases derived from 2:1 molar condensation of o-phenylenediamine and substituted salicylaldehydes have been synthesized and characterized by physico-chemical techniques such as elemental analysis

A planar Schiff base platinum(II) complex: Crystal structure, cytotoxicity and interaction with DNA

A new platinum(II) complex of salphen derivative, namely Schiff base ligand that derived from o-phenylenediamine and 5-chlorosalicylaldehyde was synthesized. The complex possessed a planar mononuclear structure. The in vitro cytotoxicities of the complex

Iridium(I) homobinuclear complexes containing salen-type ligands as bridge

New binuclear iridium(I) complexes with general formula [Ir2(η4-cod)2(μ-SB)] (1–12) derived from the reactions of tetradentate Schiff bases ligands [N,N′-ethylenebis(5-R-salicylideneimine)] (5,5′-R-salenH2), [N,N′-1,3-propylenebis(5-R-salicylideneimine)] (5,5′-R-salpenH2), and [N,N′-o-phenylenebis(5-R-salicylideneimine)] (5,5′-R-salphenH2) (R = H, MeO, Cl, NO2) with [Ir(cod)(μ-Cl)]2 were synthesized. The homobinuclear nature of this iridium complexes was supported by elemental analysis, FAB-Mass and 1H NMR spectrometry. Full characterization was accomplished by IR spectroscopy, 13C NMR and bidimensional NMR experiments (COSY, HSQC, HMBC and NOESY). In addition, iridium complex [(Ir(η4-cod)2(μ-5,5′-MeO-salen)] (2) was characterized by X-ray crystallography, showing that ethylene bridge is a s-trans conformation, and that the Schiff base ligand act as a bridging N,O-bidentate ligand toward two iridium atoms, and 1,5-cyclooctadiene (cod) ligand complete the coordination sphere of metal center. The effect of the substituent groups on salicylaldiminate fragments has been studied by 13C{1H} NMR shift and Hammett sigma correlations for each series of complexes.

Importance of ground state stabilization in the oxovanadium(IV)-salophen mediated reactions of phenylsulfinylacetic acids by hydrogen peroxide – Non-linear Hammett correlation

A systematic study on the oxidative decarboxylation of a series of phenylsulfinylacetic acids (PSAA) by hydrogen peroxide with four oxovanadium(IV)-salophen catalysts in 100% acetonitrile medium is presented. The hydroperoxovanadium(V)-salophen generated from the reaction mixture is identified as the bonafide active oxidizing species. Introduction of electron donating groups (EDG) in the oxovanadium(IV)-salophen catalyst and electron withdrawing groups (EWG) in PSAA enhances the reactivity, whereas EWG in the catalyst and EDG in PSAA have a retarding effect on the reaction. A Hammett correlation displays a non-linear downward curvature, which consists of two intersecting straight lines and the ρ value shifts from small positive to moderately high as the substituents change from EWG to EDG. The importance of the ground state stabilization of PSAA is inferred from a linear Yukawa–Tsuno plot. Based on the observed substituent effects and the spectral changes, a mechanism involving electrophilic attack of PSAA on the nucleophilic peroxo oxygen atom of the vanadium complex in the rate determining step followed by oxygen atom transfer is proposed.

Salophen and salen oxo vanadium complexes as catalysts of sulfides oxidation with H2O2: Mechanistic insights

The application of V(V) catalysts in oxidation of sulfides with peroxides offers an efficient procedure, that is compatible with different functional groups, and leads to good yields and selectivities. However, the understanding of the factors affecting the reactivity of different catalysts is still far to be complete. An experimental and theoretical study on a series of V(V) complexes containing variously substituted salen and salophen ligands is reported with the aim to correlate the activity of the catalysts with the electronic character of the vanadium center. The results obtained indicate that steric factors play a major role in determining the outcome of the reaction, often overcoming the electronic effects. Theoretical results suggest the intervention in the catalytic cycle of an hydroperoxo vanadium species.

Zirconium(IV)-modified silica gel: Preparation, characterization and catalytic activity in the synthesis of some biologically important molecules

Zirconium modified silica gel was prepared by the grafting method and the resulting organic-inorganic hybrid material was found to be a highly effective catalyst for the range of organic transformations such as syntheses of coumarins, quinoxalines and 2,4

Carbonyl and thiocarbonyl compounds XX. Reaction of hydroxybenzaldehydes with o-phenylenediamine; newer aspects in benzimidazole synthesis

The nature of the products of the uncatalysed reaction of the o-hydroxybenzaldehydes 1a-d with o-phenylenediamine in boiling ethanol is mainly dependent on the molar ratio of the reactants and the nature of the substituents at the phenyl ring of the aldeh