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• 13097-10-4 3-anilino-2-thioxo-1,3-thiazolidin-4-one 
• 100-01-6 4-nitro-aniline 

Relevant academic research and scientific papers

Polymeric complexes - LXI. Supramolecular structure, thermal properties, SS-DNA binding activity and antimicrobial activities of polymeric complexes of rhodanine hydrazone compounds

A series of new ligands 5-(4′-alkylphenylazo)-3-phenylamino-2-thioxothiazolidin-4-one (HLn) were synthesized from the coupling of 3-phenylamino-2-thioxothiazolidin-4-one with aniline and its p-derivatives. These ligands and their Co(II) polymeric complexes of the [(Co)2(Ln)2(HLn)(CH3COO)2(H2O)2]n have been deduced from elemental analyses, IR, 1H-NMR, X-ray diffraction and mass spectra as well as magnetic and thermal measurements. IR and 1H NMR studies reveal that the ligands (HLn) exist in the tautomeric enol/hydrazo form in both states with intramolecular hydrogen bonding. The important infrared (IR) spectral bands imply that HLn is coordinated to the metal ion in a monobasic tetradentate via NH (hydrazone), oxygen of the carbonyl group (CO), nitrogen of the NH (3-phenylamine) and thion sulfur (CS) group. The complexes are polymeric, non-electrolytes, paramagnetic and octahedral six-coordinated. The molecular and electronic structures of the investigated compounds (HLn) were also studied using quantum chemical calculations. The salmon sperm DNA (SS-DNA) binding activity of the ligands (HLn) was studied by absorption spectra. The interaction between ligands (HLn) and SS-DNA shows hypochromism effect coupled with obvious bathochromism. The values of binding constant are correlated with Hammett's constant (σR). The cytotoxic activity of ligands (HLn) and their Co(II) complexes were tested against two human cancer HePG-2 (Hepatocellular carcinoma) and MCF-7 (breast cancer). The antioxidant activities of ligands (HLn) and their Co(II) complexes were performed by ABTS method. The antimicrobial activity of ligands HLn and their Co(II) complexes were tested against Gram negative bacteria (Escherichia coli), Gram positive bacteria (Staphylococcus aureus) and yeast (Candida albicans).

Potentiometric, thermodynamics and theoretical calculations of some rhodanine derivatives

A series of 5-(4′-alkylphenylazo)-3-phenylamino-2-thioxothiazolidin-4-one (HLn) have been prepared and characterized by elemental analysis, 1H NMR and IR spectra. X-ray diffraction pattern of ligand (HL2) was studied. The geometrical structures of these ligands are carried out by HF method with 3-21G basis set. Proton-ligand dissociation constant of ligands (HLn) and their metal-ligand stability constants of Mn2+, Co2+, Ni2+ and Cu2+ have been determined potentiometrically in 0.1 M KCl and 30% (v/v) DMSO-water mixture at 298, 308 and 318 K. The stability constants of the formed complexes increase with the order: Mn2+ 2+ 2+ 2+. The effect of temperature was studied and the corresponding thermodynamic parameters (ΔG, ΔH and ΔS) were derived and discussed. The dissociation process is non-spontaneous, endothermic and entropically unfavorable. The formation of the metal complexes has been found to be spontaneous, endothermic and entropically favorable. Proton-ligand dissociation constant (pKH) of the ligands increases according to the following order p-(OCH3 > H > NO2) as expected from Hammett's constant (σR).

Stereochemistry of new nitrogen containing heterocyclic compound: XII. Polymeric uranyl complexes of hydrazone compounds

Several dioxouranium(VI) heterochelates with tetradentate monobasic hydrazone compounds (HLn) have been synthesized. The heterochelates of the type [(UO2)2(HLn)(Ln) 2(OAc)2(OHsu