855789-56-9

Usage

Uses

Used in Pharmaceutical Industry:
1,2,4-Triazolo[4,3-a]pyridine, 3-(chloroMethyl)is used as a lead compound for drug discovery and development due to its diverse biological activities and potential for further chemical modifications. Its antiviral, antibacterial, and antifungal properties make it a valuable candidate for the creation of new therapeutic agents to combat various infectious diseases.
Used in Agrochemical Industry:
In the agrochemical industry, 1,2,4-Triazolo[4,3-a]pyridine, 3-(chloroMethyl)is used as a starting material for the synthesis of pesticides and other agrochemicals. Its broad-spectrum antimicrobial properties can be harnessed to develop new products for crop protection and disease control in agriculture.
Used in Chemical Synthesis:
1,2,4-Triazolo[4,3-a]pyridine, 3-(chloroMethyl)is used as a building block in chemical synthesis for the creation of more complex molecules. The chloromethyl group provides a reactive site that can be further modified to produce a variety of chemical entities with different applications in various fields, such as pharmaceuticals, materials science, and specialty chemicals.

Upstream product

• 74974-54-2 2-chloro-1,1,1-trimethoxyethane 
• 109-09-1 2-chloropyridine 
• 4930-98-7 pyrid-2-ylhydrazine 

Relevant academic research and scientific papers

THERAPEUTIC COMPOUNDS

The present invention relates to compounds that are Nrf2 activators. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with Nrf2 activation.

A facile synthesis of amide derivatives of [1,2,4]triazolo[4,3-a]pyridine

A facile synthesis for preparation of amide derivatives of [1,2,4]triazolo[4,3-a]pyridine can be achieved by the nucleophilic displacement of chloromethyl derivative with methyl amine followed by the reaction with acid analogues in the presence of 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (HATU). Reaction of 2-chloropyridine with hydrazine hydrate (99 %) gave 2-hydrazinopyridine (2). Compound 3 was obtained in good yields by treating 2-hydrazinopyridine with chloroacetyl chloride. Further 3-chloromethyl-[1,2,4]triazolo[4,3-a]pyridine (4) is obtained by treatment of compound 3 with POCl3. Nucleophilic displacement of compound 4 with methyl amine gave methyl-[1,2,4]triazolo[4,3-a]pyridin-3-ylmethyl-amine (5). Finally protecting and deprotecting of compound 5 with Boc anhydride and HCl in dioxane gives hydrochloride salt of compound 5 i.e. (6) The reaction of hydrochloride salt of methyl-[1,2,4]triazolo[4,3-a]pyridin-3-ylmethyl-amine with 10 different acids yields amide analogues.

NOVEL 2-(PIPERAZIN-1-YL)- AND 2-([1,4]DIAZEPAN-1-YL)- IMIDAZO[4,5-D]PYRIDAZIN-4-ONE, PRODUCTION AND USE THEREOF AS MEDICAMENT FOR THE TREATMENT OF DIABETES MELLITUS

The invention relates to substituted imidazo[4,5-d]pyridazin-4-ones of general formula (I), in which R1 to R3 and n are as defined in claims 1 to 8, the tautomers, enantiomers, diastereomers, mixtures and salts thereof which have useful pharmacological properties, in particular, an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).