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8(R,S)-Hydroxy-11(S),12(S)-Epoxyeicosa-5Z,9E,14Z-Trienoic Acid, also known as Hepoxilin A3, is a nonclassic eicosanoid hormone that plays a significant role in various physiological processes, particularly in inflammation. It exhibits both pro-inflammatory and anti-inflammatory properties, depending on the tissue or cell type. Hepoxilin A3 is also involved in insulin secretion and is produced in the brain under oxidative stress conditions.

85589-24-8

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85589-24-8 Usage

Uses

Used in Inflammation Regulation:
Hepoxilin A3 is used as an inflammation modulator in different tissues. In the skin, it acts as a pro-inflammatory agent, while in human neutrophils, it serves as an anti-inflammatory agent. This dual role allows for the fine-tuning of inflammatory responses in various physiological contexts.
Used in Insulin Secretion:
Hepoxilin A3 is used as a potent insulin secretagogue, playing a crucial role in the regulation of glucose homeostasis. Its ability to stimulate insulin secretion makes it a potential target for the development of therapies for diabetes and other metabolic disorders.
Used in Brain Function and Oxidative Stress:
Hepoxilin A3 is produced in the brain under oxidative stress conditions, suggesting its involvement in neuroprotection and the maintenance of brain function. Further research is needed to explore its potential applications in the context of neurodegenerative diseases and brain health.
Used in Pharmaceutical Industry:
The unique properties of Hepoxilin A3 make it a promising candidate for the development of pharmaceutical agents targeting inflammation, diabetes, and brain disorders. Its multifaceted role in physiological processes offers opportunities for the creation of novel therapeutic approaches.

Check Digit Verification of cas no

The CAS Registry Mumber 85589-24-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,5,8 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 85589-24:
(7*8)+(6*5)+(5*5)+(4*8)+(3*9)+(2*2)+(1*4)=178
178 % 10 = 8
So 85589-24-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/b9-7+,10-6+,16-15+

85589-24-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name hepoxilin A3

1.2 Other means of identification

Product number -
Other names Pyranine concentrated

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:85589-24-8 SDS

85589-24-8Downstream Products

85589-24-8Relevant academic research and scientific papers

TOTAL SYNTHESIS OF BIOLOGICALLY ACTIVE METABOLITES OF ARACHIDONIC ACID. THE TWO 8-HYDROXY-11,12(S,S)-EPOXYEICOSA-5,14(Z),9(E)-TRIENOIC ACIDS.

Corey, E. J.,Su, Wei-guo

, p. 5119 - 5122 (2007/10/02)

An efficient and simple total synthesis of the two C(8) diastereomers of 3, of interest as possible hormonal releasing agents, is described.

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