85590-25-6

Upstream product

• 33868-76-7 1-(4-methoxyphenyl)-3,3-bis(methylsulfanyl)propenone 
• 106-49-0 p-toluidine 

Downstream Products

• 85590-31-4 (E)-2-[1-(4-Methoxy-benzoyl)-2,2-bis-p-tolylamino-vinyl]-but-2-enedioic acid dimethyl ester 
• 85590-40-5 5-(4-Methoxy-benzoyl)-2-oxo-1-p-tolyl-6-p-tolylamino-1,2-dihydro-pyridine-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

PIDA-Mediated Formal Olefinic C=C Bond Cleavage of α-Oxo-Ketene N,N-Acetals toward Substituted Oxazolines

The hypervalent iodine reagent PhI(OAc)2 (PIDA) mediated the formal oxidative C=C bond cleavage and subsequent cyclization of internal olefins, that is, α-oxo-ketene N,N-acetals, which afforded substituted oxazolines. Isothiazoline derivatives were obtained from the reactions of α-thioxo-ketene N,N-acetals with PIDA under the same conditions. Hydrolysis of the resultant oxazoline derivatives led to highly functionalized oxazolones. A plausible mechanism was proposed based upon the formation of isothiazoline-type intermediates.