855900-48-0Relevant academic research and scientific papers
Bidentate hydroxyalkyl NHC ligands for the copper-catalyzed asymmetric allylic substitution of allyl phosphates with grignard reagents
Magrez, Magaly,Le Guen, Yann,Basle, Olivier,Crevisy, Christophe,Mauduit, Marc
, p. 1199 - 1203 (2013)
Demonstrating their potential: Bidentate alkoxy NHC ligands have been used in the copper-catalyzed asymmetric allylic alkylation of allyl phosphates with Grignard reagents (see scheme). The method provides access to tertiary and quaternary chiral centers with high regio- and enantioselectivity. The system is also applied to the synthesis of chiral E,E-dienes, a key structural motif prevalent in natural products. Copyright
