85591-54-4Relevant academic research and scientific papers
Discovery and SAR of small molecule PAR1 antagonists
Rilatt, Ian,Mirabel, Etienne,Grand, Bruno Le,Perez, Michel
scheme or table, p. 903 - 906 (2010/07/20)
High-throughput screening resulted in the identification of a small molecule inhibitor of PAR1. Optimisation of the initial hit led to the discovery of compounds 34 and 49, which displayed antithrombotic activity in an arteriovenous shunt model in the rat after iv administration.
Ionic liquid promoted regio- and stereo-selective thiolysis of epoxides-A simple and green approach to β-hydroxy- and β-keto sulfides
Ranu, Brindaban C.,Mandal, Tanmay,Banerjee, Subhash,Dey, Suvendu S.
, p. 278 - 283 (2008/02/11)
A variety of epoxides underwent facile cleavage by thiols under the catalysis of 1-methyl-3-butylimidazolium bromide, [bmIm]Br, to produce the corresponding β-hydroxy sulfides with high regio- and stereo-selectivity. On the other hand, a specially designed basic ionic liquid, [bmIm]OH, efficiently catalyzes the thiolysis of ,β-epoxy ketones providing β-keto sulfides through simultaneous retro-aldol cleavages. The reactions are clean, high yielding, and do not require any organic solvent. The catalyst is also recycled. CSIRO 2007.
Steric effects in the diastereoselective reduction of β-ketosulfones
Grossert, J. Stuart,Dharmaratne, H. Ranjith W.,Cameron, T. Stanley,Vincent, Beverly R.
, p. 2860 - 2869 (2007/10/02)
The stereochemical course of the reduction of ketones adjacent to a chiral center normally shows some diastereoselectivity (described by Cram's rule), the degree of which is dependent on the structure of the ketone and on the reaction conditions; the selectivity in acyclic species is often not very great.In this paper, we described the sodium borohydride reduction of four acyclic β-ketosulfones, containing a chiral center at the α-position, in which the products are formed with high diastereoselectivity.Reasons for this selectivity became apparent when we were able to show that these ketosulfones apparently exist predominantly in the same conformation in solution as in the solid state.This conformation requires that the preferred trajectory for nucleophilic attack on the carbonyl group leads to reaction on the re face, to yield the threo diastereomer of the β-hydroxysulfone.The results that led to these conclusions were obtained from stuctural studies by X-ray crystallography, as well as by detailed 1H and 13C nuclear magnetic resonance spectroscopy.In some cases, the latter spectra were run both in solution and in the solid state.
INTRODUCTION OF SULFUR IN COMPOUNDS WITH REACTIVE HALOGEN ATOMS VIA THE t-BUTYLTHIOLATE ANION
Becher, Jan,Lundsgaard, John
, p. 131 - 138 (2007/10/02)
The preparation of t-butylthioethers from examples of halogen substituted heterocycles are described.S-Dealkylation of the t-butylthioethers readily takes place by pyrolyses with catalytic amounts of aluminum chloride or p-toluenesulfonic acid.
