85591-55-5Relevant academic research and scientific papers
Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: Synthesis and biological evaluation
Bhansali, Pravin,Hanigan, Christin L.,Casero, Robert A.,Tillekeratne, L. M. Viranga
supporting information; experimental part, p. 7453 - 7463 (2012/01/03)
The histone deacetylase inhibitor largazole 1 was synthesized by a convergent approach that involved several efficient and high yielding single pot multistep protocols. Initial attempts using tert-butyl as thiol protecting group proved problematic, and synthesis was accomplished by switching to the trityl protecting group. This synthetic protocol provides a convenient approach to many new largazole analogues. Three side chain analogues with multiple heteroatoms for chelation with Zn2+ were synthesized, and their biological activities were evaluated. They were less potent than largazole 1 in growth inhibition of HCT116 colon carcinoma cell line and in inducing increases in global H3 acetylation. Largazole 1 and the three side chain analogues had no effect on HDAC6, as indicated by the lack of increased acetylation of α-tubulin.
Kinetic resolution of β- and γ-hydroxy sulfides by fungal lipase from Humicola lanuginosa
Singh, Satwinder,Kumar, Subodh,Chimni, Swapandeep Singh
, p. 231 - 240 (2007/10/03)
Racemic β- and γ-hydroxy sulfides were resolved by Humicola lanuginosa lipase catalyzed transesterification using vinyl acetate both as acyl donor and solvent. The effect of substituents and spacer length on rate of reaction and enantioselectivity is obse
