856165-68-9Relevant academic research and scientific papers
TRIAZOLE OXADIAZOLES DERIVATIVES
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Page/Page column 100, (2009/07/25)
The invention relates to compounds of formula (I), wherein R1, R2, Ra, Rb, X have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes
Yan, Lin,Huo, Pei,Doherty, George,Toth, Lesile,Hale, Jeffrey J.,Mills, Sander G.,Hajdu, Richard,Keohane, Carol A.,Rosenbach, Mark J.,Milligan, James A.,Shei, Gan-Ju,Chrebet, Gary,Bergstrom, James,Card, Deborah,Quackenbush, Elizabeth,Wickham, Alexandra,Mandala, Suzanne M.
, p. 3679 - 3683 (2007/10/03)
A series of 3-arylpropionic acids were synthesized as S1P1 receptor agonists. Structure-activity relationship studies on the pendant phenyl ring revealed several structural features offering selectivity of S1P1 binding against S1Psu
