856168-33-7Relevant academic research and scientific papers
Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor
Vachal, Petr,Toth, Leslie M.,Hale, Jeffrey J.,Yan, Lin,Mills, Sander G.,Chrebet, Gary L.,Koehane, Carol A.,Hajdu, Richard,Milligan, James A.,Rosenbach, Mark J.,Mandala, Suzanne
, p. 3684 - 3687 (2007/10/03)
Novel series of sphingosine-1-phosphate (S1P) receptor agonists were developed through a systematic SAR aimed to achieve high selectivity for a single member of the S1P family of receptors, S1P1. The optimized structure represents a highly S1P
(3,4-DISUBSTITUTED)PROPANOIC CARBOXYLATES AS S1P (EDG) RECEPTOR AGONISTS
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Page/Page column 154, (2008/06/13)
The present invention encompasses compounds of Formula A: A as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activities by modulating leukocyte trafficking, sequestering lymphocytes in secondary lymphoid tissues, and enhancing vascular integrity. The invention is also directed to pharmaceutical compositions containing such compounds and methods of treatment or prevention.
