85619-95-0Relevant academic research and scientific papers
Stereospecific Synthesis of Tetrahydrobenzisoquinoline Derivatives
Gellert, Emery,Kumar, Naresh,Tober, Deirdre
, p. 157 - 163 (2007/10/02)
A new synthesis of optically active tetrahydrobenzisoquinolines is described.Cyclization of N-arylalkylalanines with retention of configuration was achieved by mild intramolecular Friedel-Crafts acylation.The compounds synthesized this way represent simple analogues of phenanthroindolizidine alkaloids.Some features of the n.m.r. spectra of cyclized and open-chain intermediates are discussed.
