856208-34-9Relevant academic research and scientific papers
1H-naphtho[1,2-e][1,3]oxazines: Synthesis, nuclear magnetic resonance, antimicrobial and docking study
Monika,Verma, Vikas,Kumar, Devinder,Kumar, Ashwani
, p. 143 - 152 (2018/09/14)
The paper describes the synthesis of a series of 1H-naphtho[1,2-e][1,3]oxazines (8) and characterization utilizing Fourier-transform infrared, nuclear magnetic resonance (NMR), 2D NMR, and mass spectral techniques. These compounds were tested for in vitro antibacterial activity against Gram-negative Escherichia coli [MTCC 40], Gram-positive Bacillus subtilis [MTCC 2063], Staphylococcus aureus [MTCC 3160] and in vitro antifungal activity against Aspergillus Niger [MTCC 281], Candida albicans [MTCC 183]. The compounds 8c and 8i demonstrated significant antibacterial activity and 8c, 8i, and 8k showed moderate antifungal activity among the different 1H-naphtho[1,2-e][1,3]oxazines synthesized. Further to find out plausible mechanism of action for antimicrobial activity of synthesized compounds and to predict the binding mode, docking simulations of most active compounds 8c and 8i were carried out against active site of topoisomerase II DNA gyrase B enzyme.
Synthesis of 1-(α-Aminobenzyl)-2-naphthol derivatives, their structure in crystal and in solution
Metlushka,Sadkova,Shaimardanova,Tufatullin,Zheltukhin,Kataeva,Alfonsov
, p. 80 - 85 (2015/01/30)
The series of tautomeric 1,3-diarylnaphthoxazines (the Betti base precursors) was obtained by the interaction of 2-naphthols and 1,3,5-trisaryl-2,4-diazapenta-1,4-dienes. Their structure has been established in solid state and solution.
Synthesis, antimicrobial and cytotoxicity study of 1,3-disubstituted-1H- naphtho[1,2-e][1,3]oxazines
Verma, Vikas,Singh, Kuldeep,Kumar, Devinder,Klap?tke, Thomas M.,Stierstorfer, J?rg,Narasimhan, Balasubramanian,Qazi, Asif Khurshid,Hamid, Abid,Jaglan, Sundeep
, p. 195 - 202 (2013/01/15)
A series of new 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines (3 and 7) was synthesized in good yields and the structure was determined with the help of NMR, 2D-NMR, HRMS studies and X-ray crystallography. These compounds were tested in vitro for their
Efficient synthesis of naphtho[1,2-e][1,3]oxazine derivatives via a chemoselective reaction with the aid of low-valent titanium reagent
Shi, Daqing,Rong, Shaofeng,Dou, Guolan,Wang, Manman
scheme or table, p. 25 - 30 (2010/10/03)
A series of new naphtho[1,2-e][1,3]oxazine derivatives such as trans-1,3-diaryl-1H-naphtho[1,2-e][1,3]oxazine-2(3H)-carbonyl chloride, 1-aryl-2-benzyl-1,2- dihydronaphtho[1,2-e][1,3]oxazine-3-one, and trans-1,3-diaryl-1H-naphtho[1,2-e] [1,3]oxazine-2(3H)-
