856215-39-9

Upstream product

• 110-91-8 morpholine 
• 856215-37-7 1-[1-(4-trifluoromethyl-phenyl)-methanoyl]-piperidine-4-carboxylic acid (6-chloro-pyridin-3-yl)-amide 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 521322-72-5 1-[1-(4-trifluoromethyl-phenyl)-methanoyl]-piperidine-4-carboxylic acid ethyl ester 
• 856215-36-6 1-(4-(trifluoromethyl)benzoyl)piperidine-4-carboxylic acid 
• 856215-38-8 C₁₄H₁₃ClF₃NO₂ 
• 1126-09-6 4-carbethoxypiperidine 

Downstream Products

• 856215-40-2 6-(4-morpholinyl)-N-[(1-{[4-(trifluoromethyl)phenyl]methyl}-4-piperidinyl)methyl]-3-pyridinamine 

Relevant academic research and scientific papers

COMPOUNDS HAVING MORPHOLINYL AND PIPERIDINYL GROUPS FOR USE AS GLYT1 AND GLYT2 INHIBITORS

The invention provides a compound of formula (I) or a salt or solvate thereof, wherein R1, R3 and R4, Het, X and Ar are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters

N-[6-(4-MORPHOLINYL)-3-PYRIDINYL]-2-(TETRAHYDRO-2H-PYRAN-4-YL)-N-[(1-{[PHENYL]METHYL}-4-PIPERIDINYL)METHYL] ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS GLYT1 TRANSPORT INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS SUCH AS SCHIZOPHRENIA

The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1 is selected from the group consisting of optionally substituted C1-8alkyl, optionally substituted C3-8 cycloalkyl, optionally substi