85628-36-0Relevant academic research and scientific papers
TOLL-LIKE RECEPTOR 8 (TLR8)-SPECIFIC ANTAGONISTS AND METHODS OF MAKING AND USES THEREOF
-
Page/Page column 51; 57-58, (2019/05/22)
Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.
Synthesis and Reactivity of 2-Aroylbenzoic Acid, III. 2-(4-Hydroxy-3,5-dimethylbenzoyl)benzoic Acid
Ruminski, Jan K.
, p. 970 - 979 (2007/10/02)
Friedel-Crafts 2-carboxybenzoylation of 2,6-xylenol with phthalic anhydride resulted in the formation of a new p-acylphenol type compound: 2-(4-hydroxy-3,5-dimethylbenzoyl)benzoic acid (1) (74percent yield).Similar reactions of 2,6-xylenol with tetrabromo- and tetrachlorophthalic anhydride gave the benzoic acid derivatives 13 and 14, respectively.Another practical and efficient (93percent) method for preparation of compound 1 was semi-Stieglitz rearrangement of the known 3,3-bis(4-hydroxy-3,5-dimethylphenyl)phthalide (9).Reactions of the acid 1 have been investigated, leading to its derivatives 2 - 12.
