85629-92-1Relevant academic research and scientific papers
Modular Ligands for Dirhodium Complexes Facilitate Catalyst Customization
Bachmann, Daniel G.,Schmidt, Pascal J.,Geigle, Stefanie N.,Chougnet, Antoinette,Woggon, Wolf-Dietrich,Gillingham, Dennis G.
, p. 2033 - 2038 (2015/06/23)
Although stereoselectivity is often the focus of ligand optimizations in catalysis, ligand modularity can be used to control many other properties of catalysts. For example, solubility, amenability to purification, and steric shielding of sensitive catalytic intermediates are all important, but seldom appreciated, functions of ligands. We describe a brief and modular approach to various homo- and heteroleptic lantern-type rhodium(II) complexes and perform benchmarking studies with the new catalysts in common rhodium(II)-catalyzed reactions. We demonstrate the power of ligand modularity by creating catalysts customized for aqueous catalysis or for applications in chemical biology.
Dirhodium (II) carboxylate complexes as building blocks. cis-Chelating dicarboxylic acids designed to bridge the dinuclear core
Bickley, Jamie,Bonar-Law, Richard,McGrath, Thomas,Singh, Nirmal,Steiner, Alexander
, p. 425 - 433 (2007/10/03)
The syntheses and crystal structures of a series of dicarboxylic acids of general structure HO2CCR2OArOCR2CO 2H (LH2) designed to span a pair of cis sites on the dirhodium(II) tetracarboxylate framewo
Phenylenebis(oxy)bis[2,2-dimethylpentanoic acid]s: Agents that elevate high-density lipoproteins
Sircar,Hoefle,Maxwell
, p. 1020 - 1027 (2007/10/02)
A series of phenylenebis(oxy)bis[2,2-dimethylpentanoic acid]s have been synthesized and evaluated as potential hypolipidemic agents. Compound 18 (CI-924) was found to be the most potent compound in this series. In rats, compound 18 is not only reduced low-density lipoprotein cholesterol but also increased high-density lipoprotein (HDL cholesterol. Comparative studies in rats indicated 18 produced an equal elevation of HDL cholesterol at one-third of the dose required of gemfibrozil. Structure-activity relationships are discussed.
