856359-61-0Relevant academic research and scientific papers
Controlled release of hydrogen sulfide significantly reduces ROS stress and increases dopamine levels in transgenic: C. elegans
Ali, Rafat,Pal, Hilal Ahmad,Hameed, Rohil,Nazir, Aamir,Verma, Sandeep
supporting information, p. 10142 - 10145 (2019/08/30)
Hydrogen sulfide, an endogenous signalling molecule, is central to several pathophysiological processes in mammalian systems. It scavenges reactive oxygen species and is known to ameliorate dopaminergic neuronal degeneration in neurotoxin-induced Parkinson's disease models. The rapid volatilization of H2S from spontaneously releasing sulfide salts being a challenge, we describe peptide conjugates which exhibit tris(2-carboxyethyl)phosphine mediated "slow and sustained" H2S release. These conjugates reduced hydrogen peroxide-induced oxidative stress and significantly increased dopamine levels in transgenic C. elegans.
NEW ANTICANCER COMPOUNDS
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Page/Page column 30, (2009/06/27)
The present invention relates to new polysulf urated compounds containing 2 or more sulphur atoms belonging to the class of organic thiosulf onates, or dithiole-thione derivatives cyclic or linear, or trithiocarbonates for the use alone or in combination with other anticancer treatments for the treatment and/or prevention of cancer and inflammatory diseases.
