856426-94-3

Upstream product

• 856426-93-2 (2R,3S,4aR,8aS)-2-{3-[(2S,3R)-2-((S)-3-Benzyloxy-1-methyl-propyl)-tetrahydro-pyran-3-yloxy]-3-phenylsulfanyl-propyl}-3-methyl-octahydro-pyrano[3,2-b]pyran-3-ol 
• 922-67-8 propynoic acid methyl ester 
• 856427-04-8 tert-Butyl-dimethyl-((2S,3R)-2-vinyl-tetrahydro-pyran-3-yloxy)-silane 
• 257280-84-5 ((2R,3S,4aR,8aS)-3-Hydroxy-3-methyl-octahydro-pyrano[3,2-b]pyran-2-yl)-acetic acid ethyl ester 
• 257280-83-4 (E)-3-[(2R,3S)-2-(2-Oxo-propyl)-tetrahydro-pyran-3-yloxy]-acrylic acid ethyl ester 
• 125878-02-6 2-((2R,3S)-3-(tert-butyldimethylsiloxy)tetrahydropyran-2-yl)acetaldehyde 
• 125877-98-7 (2'R,3'S)-<3'-(tert-butyldimethylsilyloxy)tetrahydropyran-2'-yl>ethanol 
• 121422-51-3 (2S,3R)-3-hydroxy-2-vinyloxane 
• 856427-08-2 3-[(2R,3S,4aR,8aS)-3-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-propan-1-ol 
• 856426-90-9 ((2R,3S,4aR,8aS)-2-Allyl-3-methyl-octahydro-pyrano[3,2-b]pyran-3-yloxy)-tert-butyl-dimethyl-silane 
• 856426-85-2 (E)-3-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-acrylic acid methyl ester 
• 856426-83-0 (2S,3R)-2-((S)-3-Benzyloxy-1-methyl-propyl)-tetrahydro-pyran-3-ol 
• 856427-07-1 1-((2R,3S)-3-Hydroxy-tetrahydro-pyran-2-yl)-propan-2-one 
• 856427-09-3 ((2R,3S,4aR,8aS)-2-{3-[(2S,3R)-2-((S)-3-Benzyloxy-1-methyl-propyl)-tetrahydro-pyran-3-yloxy]-3-phenylsulfanyl-propyl}-3-methyl-octahydro-pyrano[3,2-b]pyran-3-yloxy)-tert-butyl-dimethyl-silane 

Relevant academic research and scientific papers

Convergent synthesis of the BCDEFGHIJ-ring polyether core of gambieric acids, potent antifungal polycyclic ethers

A convergent synthesis of the nonacyclic BCDEFGHIJ-ring polyether core of gambieric acids, potent antifungal polycyclic ether marine natural products, has been achieved. The present synthesis involved as key features: (i) convergent union of the BCD- and GHIJ-ring fragments through esterification, (ii) construction of the E-ring as a lactone form via reductive acetylation, (iii) stereoselective allylation to establish the C26 stereocenter, and (iv) ring-closing metathesis reaction to form the nine-membered F-ring.

Studies toward the total synthesis of gambieric acids, potent antifungal polycyclic ethers: Convergent synthesis of the CDEFG-Ring system

(Chemical Equation Presented) A convergent synthetic route to the CDEFG-ring system of gambieric acids, potent antifungal polycyclic ether marine natural products, has been developed. The present synthesis features convergent union of the CD- and G-rings