856436-16-3 Usage
Description
JAK3 INHIBITOR VI is a cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3) with an IC50 value of 27 nM. It is known to bind to the enzyme active site, preventing IL-2-induced phosphorylation of JAK3 and STAT5. JAK3 INHIBITOR VI has also been reported to inhibit IL-2-induced cell proliferation in both murine CTLL cells (IC50 = 760 nM) and human T-cells (IC50 = 250 nM). JAK3 INHIBITOR VI has demonstrated its efficacy in alleviating oxazolon-induced ear edema in mice, showing comparable results to Dexamethasone and displaying approximately 16-fold greater selectivity over JAK2.
Uses
Used in Pharmaceutical Industry:
JAK3 INHIBITOR VI is used as a research compound for studying the role of JAK3 in various cellular processes and its potential as a therapeutic target for the development of new drugs. Its ability to inhibit JAK3 and STAT5 phosphorylation makes it a valuable tool in understanding the underlying mechanisms of diseases associated with the JAK3 pathway.
Used in Immunology Research:
JAK3 INHIBITOR VI is used as an immunosuppressive agent in preclinical studies, particularly for conditions involving excessive immune responses. Its inhibitory effects on IL-2-induced cell proliferation highlight its potential in managing autoimmune and inflammatory diseases.
Used in Drug Discovery and Development:
JAK3 INHIBITOR VI serves as a lead compound in the development of novel therapeutic agents targeting JAK3. Its high potency and selectivity make it an attractive candidate for further optimization and refinement to improve its pharmacological properties and therapeutic potential.
Used in Cancer Research:
JAK3 INHIBITOR VI is used as a research tool to investigate the role of JAK3 in cancer cell proliferation and survival. Its inhibitory effects on IL-2-induced cell proliferation suggest its potential in targeting cancer cells that rely on the JAK3 pathway for growth and survival.
Used in Inflammation and Autoimmune Disease Research:
JAK3 INHIBITOR VI is used to study the involvement of JAK3 in inflammatory and autoimmune diseases. Its ability to alleviate oxazolone-induced ear edema in mice demonstrates its potential in treating conditions characterized by excessive inflammation and immune activation.
Biochem/physiol Actions
Cell permeable: yes
Check Digit Verification of cas no
The CAS Registry Mumber 856436-16-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,6,4,3 and 6 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 856436-16:
(8*8)+(7*5)+(6*6)+(5*4)+(4*3)+(3*6)+(2*1)+(1*6)=193
193 % 10 = 3
So 856436-16-3 is a valid CAS Registry Number.
