85655-97-6Relevant academic research and scientific papers
Preparation method of high-purity aryne substituted nitrile compound
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Paragraph 0013; 0037-0044; 0049-0050, (2021/01/25)
The invention relates to a preparation method of a high-purity aryne substituted nitrile compound, which is characterized by comprising the following steps: under the protection of N2, carrying out nucleophilic substitution reaction on a compound as shown in a formula (1) and a compound as shown in a formula (2) under an alkaline condition until the reaction is complete, and extracting and separating the obtained reaction solution to obtain a compound as shown in a formula (3), namely the aryne substituted nitrile compound, wherein R is a substituent and is selected from one or more of hydrogen, fluorine, bromine, chlorine, methyl, methoxy or trifluoromethyl; x is Cl, Br or I; the compound shown in the formula (2) is short-chain or long-chain halogenated alkane. Compared with the prior art, the method has the advantages of low cost, higher reaction yield, high purity, milder reaction conditions, shorter reaction time and simple preparation, and is suitable for industrial production.
