85657-59-6

Upstream product

• 57943-84-7 Benzyl Clavulanate 

Downstream Products

• 86087-51-6 dibenzyl (7RS, 16SR)-3,12-dihydroxy-9,18-dioxo-6,15-dioxa-1,10-diazatricyclo<14.2.0.0^7,10>octadeca-2,11-diene-2,11-dicarboxylate 
• 85784-64-1 dibenzyl (7RS, 16RS)-3,12-dihydroxy-9,18-dioxo-6,15-dioxa-1,10-diazatricyclo<14.2.0.0^7,10>octadeca-2,11-diene-2,11-dicarboxylate 
• 92632-77-4 benzyl 2-amino-5-hydroxy-3-oxopentanoate hydrochloride 
• 92632-78-5 benzyl 2-benzyloxycarbonylamino-5-hydroxy-3-oxopentanoate 

Relevant academic research and scientific papers

Studies on the Hydrolysis of Clavulanic Acid

1-Amino-4-hydroxybutan-2-one (14) has been identified as one of the major products from the hydrolysis of clavulanic acid in acidic, alkaline, or neutral solution.In alkaline or neutral solution, the amino ketone (14) is converted into other products, including two pyrazines, 2,5-bis(2-hydroxyethyl)pyrazine and 3-ethyl-2,5-bis(2-hydroxyethyl)pyrazine.A rationale for the formation of these products is discussed.

Nuclear Modification of Clavulanic Acid. The Preparation of Two 4,7-Fused β-Lactam Systems

The 4,7-fused β-lactam compounds benzyl 3-methoxy-9-oxo-6-oxa-1-azabicyclonon-2-ene-2-carboxylate and benzyl 3-methoxy-9-oxo-6-oxa-1-azabicyclonona-2,4-diene-2-carboxylate have been prepared by routes which utilise the total carbon-oxygen sk