856702-36-8

Upstream product

• 6306-52-1 L-valine methylester hydrochloride 
• 1492-06-4 methyl (S)-2-(2-chloroacetylamino)-2,3-dimethylbutanoate 
• 64-04-0 phenethylamine 
• 122-78-1 phenylacetaldehyde 
• 54608-35-4 N-phenethylglycine ethyl ester 
• 13734-41-3 t-Boc-L-valine 
• 856702-32-4 ethyl N'-(tert-butoxycarbonyl)-L-valyl-N-(2-phenylethyl)glycinate 

Downstream Products

• 357666-67-2 (S)-4-Isopropyl-2-phenethyl-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione 

Relevant academic research and scientific papers

Highly efficient enantioselective synthesis of 1,3-disubstituted 2,5-diketopiperazine derivatives via microwave irradiation

Chiral 2,5-diketopiperazine (2,5-DKP) derivatives have a broad range of biological activities in the medicinal field. The synthetic protocols of 1,3-disubstituted 2,5-DKPs via base-catalyzed cyclization of chloroacetamide have been reported. However, there are several drawbacks, such as an overly long reaction time, low to moderate yield, and racemization of the products. The sequence modified herein of 1,3-disubstituted 2,5-DKPs involves microwave-assisted cyclization. It increases yields and reduces reaction time. Furthermore, employing N-PMB protection prevents racemization, which frequently occurs in the base-catalyzed cyclization reaction. Consequently, the rapid synthetic method of enantiomerically pure 1,3-disubstituted 2,5-DKPs via microwave reaction was established successfully.

Microwave-assisted synthesis of 2,5-piperazinediones under solvent-free conditions

A general, efficient and environmentally friendly procedure for the synthesis of 2,5-piperazinediones is described, involving the microwave irradiation of N-Boc dipeptide esters. Georg Thieme Verlag Stuttgart.

Solvent-free, efficient synthesis of 2,5-piperazinediones from Boc-protected dipeptide esters under microwave irradiation

Microwave irradiation allows the efficient, solvent-free transformation of N-Boc dipeptide esters into 2,5-piperazinediones. The microwave-assisted conditions were found to be much better than traditional heating in terms of reaction time, yield and stere