85677-99-2

Basic information

• Product Name: Furo[3,4-b]pyridine-3-carboxylic acid, 5,7-dihydro-2-methyl-4-(3-nitrophenyl)-5-oxo-, 2-hydroxyethyl ester
• Synonyms: 2-Methyl-4-(3-nitro-phenyl)-5-oxo-5,7-dihydro-furo[3,4-b]pyridine-3-carboxylic acid 2-hydroxy-ethyl ester;2-hydroxyethyl 2-methyl-4-(3-nitrophenyl)-5-oxo-5,7-dihydrofuro-[3,4-b]-3-pyridinedicarboxylate;2-hydroxyethyl 5,7-dihydro-2-methyl-4-(3-nitrophenyl)-5-oxofuro[3,4-b]pyridine-3-carboxylate
• CAS NO: 85677-99-2
• Molecular Formula: C17H14N2O7
• Molecular Weight: 358.30200
• Mol File: 85677-99-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 659.9±55.0 °C(Predicted)
• Density: 1.464±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Furo[3,4-b]pyridine-3-carboxylic acid, 5,7-dihydro-2-methyl-4-(3-nitrophenyl)-5-oxo-, 2-hydroxyethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[3,4-b]pyridine-3-carboxylic acid, 5,7-dihydro-2-methyl-4-(3-nitrophenyl)-5-oxo-, 2-hydroxyethyl ester(85677-99-2)
• EPA Substance Registry System: Furo[3,4-b]pyridine-3-carboxylic acid, 5,7-dihydro-2-methyl-4-(3-nitrophenyl)-5-oxo-, 2-hydroxyethyl ester(85677-99-2)

Safety Data

• Hazardous Substances Data: 85677-99-2(Hazardous Substances Data)

Upstream product

• 85677-97-0 3-ethyl 5-(2-acetoxyethyl) 2-acetoxymethyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 34500-18-0 2-acetoxyethyl acetoacetate 
• 103295-53-0 (Z)-3-Amino-but-2-enoic acid 2-acetoxy-ethyl ester 

Relevant articles and documents

Ischaemia or hypoxia controlling compositions containing pyridinecarboxylic acid esters

Pyridinecarboxylic acid esters of the formula STR1 in which R is an optionally substituted aryl or heterocyclic radical, R1 and R2 are hydrogen, alkyl, aryl, aralkyl, acyloxyalkyl or hydroxyalkyl, or R1 with X forms a carb

Nimodipine: Synthesis and metabolic pathway

Key step of the synthesis of the calcium antagonistic cerebral vasodilator (±) isopropyl-2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (Bay e 9736, nimodipine) is the cyclising Michael addition. A pharmacokinetic study with 14C-nimodipine in the rat revealed as major metabolites the dihydropyridines as well as the pyridines. A potential metabolic pathway is discussed involving ether cleavage and oxidation to the pyridine form as primary biotransformation steps. Reference metabolites were synthesized using 1,4-dihydropyridines with appropriate functionalities as precursors.