856832-08-1

Usage

Structure

A derivative of isoindole-1,3-dione with an iodine atom substituted at the 4-position

Appearance

White to off-white solid

Usage

Building block in organic synthesis, with applications in pharmaceutical and agrochemical industries

Biological activity

Potential antipsychotic, anticonvulsant, and anticancer properties

Safety precautions

Handle with care due to potential health hazards, follow proper safety procedures when working with it.

Upstream product

• 58142-99-7 5-iodoisoquinoline 
• 28418-88-4 3-iodophthalic anhydride 
• 57-13-6 urea 

Downstream Products

• 1189358-88-0 N₁-[4-(4-tert-butylphenyl)-1,3-thiazol-2-yl]-2-(2-methyl-1,3-dioxo-2,3-dihydro-1H-4-isoindolyl)acetamide 
• 1189358-79-9 N₁-biphenyl-4-yl-2-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)acetamide 
• 1189358-73-3 N₁-(4-isopropylphenyl)-2-(2-methyl-1,3-dioxo-2,3-dihydro-1H-4-isoindol)acetamide 

Relevant academic research and scientific papers

JAK INHIBITOR

A JAK inhibitor comprising, as an active ingredient, a nitrogen-containing heterocyclic compound represented by formula (I) {wherein W represents a nitrogen atom or -CH-; X represents -C (=O) - or -CHR4- (wherein R4 represents a hydrogen atom, or the like); R1 represents the formula described below [wherein Q1 represents-CR8-(wherein R8 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like); Q2 represents -NR15- (wherein R15 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like); and R5 and R6 may be the same or different and each represents a hydrogen atom, halogen, carboxy, substituted or unsubstituted lower alkyl, or the like], or the like; and R2 and R3 may be the same or different and each represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like} or a pharmaceutically acceptable salt thereof.

7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity

A novel series of 7-[1H-indol-2-yl]-2,3-dihydro-isoindol-1-ones designed to be inhibitors of VEGF-R2 kinase was synthesized and found to potently inhibit VEGF-R2 and Aurora-A kinases. The structure-based design, synthesis, and initial SAR of the series are discussed.

SUBSTITUTED DIHYDRO-ISOINDOLONES USEFUL IN TREATING KINASE DISORDERS

The present invention is directed to novel substituted dihydro-isoindolone compounds of formula (I): and forms thereof, wherein Ring A, X3, R1, R2, R3, R4 and R6 are as herein defined, and their synthesis and use as protein kinase inhibitors and interactions thereof.

DIARYLSULFONES AS 5-HT2A ANTAGONISTS

Compounds of formula (I) are potent and selective antagonists of the human 5-HT2A receptor, and hence useful in treatment of a variety of adverse conditions of the CNS.