856839-64-0

Usage

Derivative of phenylethanol

It is a modified version of the phenylethanol compound, with additional functional groups attached to the phenyl ring.

Presence of bromine and nitro groups

The phenyl ring contains a bromine atom and a nitro group (-NO2), which contribute to its chemical reactivity and properties.

Common uses

Synthesis of pharmaceuticals and agrochemicals, organic reactions as a building block, and as a chiral auxiliary in asymmetric synthesis.

Physical appearance

Yellow solid at room temperature This describes the color and state of the compound when it is not dissolved in any solvent.

Solubility

Soluble in organic solvents such as ethanol and acetone This indicates that the compound can dissolve in certain organic solvents, which is important for its applications in chemical reactions.

Potential hazards

Causing skin and eye irritation Handling 2-(4-bromo-2-nitrophenyl)ethanol requires caution, as it can cause harm upon contact with the skin or eyes.

Safety precautions

Use in a well-ventilated area with proper protective equipment To minimize the risk of exposure and potential hazards, it is essential to work with 2-(4-bromo-2-nitrophenyl)ethanol in a well-ventilated space and wear appropriate personal protective equipment.

Upstream product

• 1089131-11-2 4-bromo-2-nitrophenethyl acetate 
• 50-00-0 formaldehyd 
• 60956-26-5 4-bromo-2-nitrotoluene 

Downstream Products

• 857070-77-0 2-(4-furan-3-yl-2-nitro-phenyl)-ethanol 
• 856839-67-3 2-(2-amino-4-bromo-phenyl)-ethanol 

Relevant academic research and scientific papers

Enantioselective Copper-Catalyzed Intramolecular N?H Bond Insertion: Synthesis of Chiral 2-Carboxytetrahydroquinolines

The first highly enantioselective intramolecular N?H bond insertion was realized by using copper catalysts modified with chiral spirobisoxazoline ligands, which provides a novel strategy for the synthesis of chiral 2-carboxytetrahydroquinolines. This reaction features fast reaction rate, high yield, high enantioselectivity, and mild reaction conditions. (Figure presented.).

Synthesis of indolines via a SmI2 promoted domino nitro reduction-intramolecular aza-Michael reaction

A simple and straightforward synthesis of substituted indolines based on a domino nitro reduction intramolecular aza-Michael reaction is described. The reaction employs Samarium diiodide under mild conditions for the addition of dibromoacetic acid to substituted 2-(2-nitrophenyl) acetaldehyde derivatives and their subsequent cyclization upon nitro group reduction to provide corresponding indoline heterocycles in good yields. This "one pot" strategy also permitted the expeditious synthesis of a 1,2,3,4-tetrahydroquinoline, whereas the seven-membered 2,3,4,5-tetrahydrobenzoazepines compounds were not formed under these reaction conditions.

LINCOMYCIN DERIVATIVES AND ANTIBACTERIAL AGENTS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

An objective of the present invention is to provide compounds of formula (1) or their pharmacologically acceptable salts or solvates wherein A represents aryl; R1 represents N-optionally substituted C1-6 alkyl-N-optionally substituted C1-6 alkylamino-C1-6 alkyl; R2 represents a hydrogen atom or optionally substituted C1-6 alkyl; R3 represents optionally substituted C1-6alkyl or C3-6 cycloalkyl-C1-4 alkyl; m is 1 to 3; n is 0; and p is 0 to 2. The compounds are novel lincomycin derivatives that have a potent activity against resistant Streptococcus pneumoniae, which have recently posed problems, in the treatment of infectious diseases. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.

AMINOBENZIMIDAZOLES AND BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION

Aminobenzimidazoles and benzimidazoles having inhibitory activity on RSV replication and having the formula (I) the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; wherein G is a direct b