856866-30-3Relevant academic research and scientific papers
Pyrimidine-annulated pyrrolobenzodiazepines. a new ring system related to aspergillus alkaloids
Schmidt, Andreas,Shilabin, Abbas Gholipour,Namyslo, Jan Christoph,Nieger, Martin,Hemmen, Sascha
, p. 1781 - 1789 (2007/10/03)
Pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione was converted into the corresponding C-11-monothiolactam and subsequently treated with amines to give cyclic amidines, which racemize due to the formation of tautomers (NMR, X-ray analysis) under basic conditions. We treated these amidines with bis(trichlorophenyl) malonate esters. Formation of neutral tautomers of the 1,3,8-triones of the new 4,7a,12b-triaza dibenzo[e,g]azulene ring system gave a twisted molecule with both helical and chiral structure elements (NMR, X-ray analysis), which caused a splitting of the NMR signals into two sets. Results of two X-ray single crystal analyses are presented, together with an ab initio calculation. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.
