85690-50-2Relevant academic research and scientific papers
General, Mild, and Metal-Free Synthesis of Phenyl Selenoesters from Anhydrides and Their Use in Peptide Synthesis
Temperini, Andrea,Piazzolla, Francesca,Minuti, Lucio,Curini, Massimo,Siciliano, Carlo
, p. 4588 - 4603 (2017/05/12)
A mild, practical, and simple procedure for phenyl selenoesters synthesis from several anhydrides and diphenyl diselenide was developed. This transition-metal-free method provides a straightforward entry to storable Fmoc-amino acid selenoesters which are effective chemoselective acylating reagents. An application to oligopeptide synthesis was illustrated.
Hafnium-catalyzed direct amide formation at room temperature
Lundberg, Helena,Adolfsson, Hans
, p. 3271 - 3277 (2015/06/16)
Herein, the first example of a metal-catalyzed protocol for direct amidation of nonactivated carboxylic acids at ambient temperature (26 °C) is presented. The mild reaction conditions give rise to high yields of a range of amides in reaction times as short as 90 min, employing a commercial hafnium complex, [Hf(Cp)2Cl2], as catalyst. Amino acids are transformed into their corresponding amides without racemization, and the catalyst displays full selectivity for the amidation of carboxylic acids over esters. Electronic properties of the carboxylic acids were found to have a strong influence on the rate of the amidation reaction, and the need for a balanced amount of molecular sieves was observed to be highly important for optimal reaction outcome.
STUDIES ON 4-QUINAZOLINONES. PART IX. RANEY NICKEL DESULPHURISATION OF 4-THIOQUINAZOLINES: ALUMINA CATALYSED HYDRATION OF 1,4- AND 3,4-DIHYDROQUINAZOLINES
Chakrabarty, Manas,Chakravarty, Ajit K.,Pakrashi, Satyesh C.
, p. 445 - 450 (2007/10/02)
A number of 2-substituted 3,4-dihydroquinazolines and 1,2-disubstituted 1,4-dihydroquinazolines but not the 3-mono or 2,3-disubstituted derivatives, prepared by Raney nickel desulphurisation of the corresponding 4-thioquinazolines (IV), underwent unusual
