856900-73-7Relevant academic research and scientific papers
Heterocyclizations with tosylmethyl isocyanide derivatives. A new approach to substituted azolopyrimidines
Baeza, Alejandro,Mendiola, Javier,Burgos, Carolina,Alvarez-Builla, Julio,Vaquero, Juan J.
, p. 4879 - 4882 (2005)
An efficient synthesis of substituted azolopyrimidines such as pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidines, pyrimido[1,6-a]indoles, benzo[4,5]imidazo-[1,2-c]pyrimidines, an imidazo[1,2-c]pyrimidine, and pyrazolo[1,5-c]pyrimidines is described. The method i
1-Trifluoromethylisoquinolines from α-Benzylated Tosylmethyl Isocyanide Derivatives in a Modular Approach
Wang, Lin,Studer, Armido
supporting information, p. 5701 - 5704 (2017/10/25)
The preparation of various 1-trifluoromethylisoquinolines from α-benzylated tosylmethyl isocyanide derivatives and the commercial Togni reagent using a radical cascade is reported. The starting isocyanides are readily prepared in a modular sequence from commercial tosylmethyl isocyanide via sequential double α-alkylation, and the radical reaction proceeds under mild conditions with high efficiency without any transition-metal catalyst via electron catalysis. This valuable protocol has been successfully applied to the total synthesis of CF3-mansouramycin B.
