856900-92-0Relevant academic research and scientific papers
Anionic domino C-O-heterocyclization approach for the synthesis of 5-vinyl isoxazolines
Qazi, Naveed Ahmed,Singh, Parvinder Pal,Jan, Sumira,Kumar, H. M. Sampath
, p. 1449 - 1451 (2007)
5-Vinyl isoxazolines were isolated in high yields through domino nucleophilic addition-anionic C-O-heterocyclization, when allyl organometallics derived from trans-1,4-dihalobutene were reacted with nitrile oxides. Georg Thieme Verlag Stuttgart.
Reaction of allenylmagnesium and allenylindium bromides with nitrile oxides: synthesis of novel 5-butynyl- and 5-methylisoxazoles
Sampath Kumar,Singh, Parvinder Pal,Shafi, Syed,Reddy, Pitta Bhaskar,Shravankumar, Kankala,Reddy, Doma Mahender
, p. 887 - 890 (2007/10/03)
5-Butynylisoxazoles were obtained in high yields through a domino addition, C-O heterocyclization involving allenylmagnesium bromide and benzonitrile oxide in dry THF, in which the corresponding 5-methylisoxazoles were isolated in trace amounts. However, when the reactions were attempted in aqueous media using allenylindium bromide, 5-methylisoxazoles were formed as the sole products in high yields.
