856931-65-2Relevant academic research and scientific papers
Design and synthesis of pyridin-2-yloxymethylpiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication
Skerlj, Renato,Bridger, Gary,Zhou, Yuanxi,Bourque, Elyse,Langille, Jonathan,Fluri, Maria Di,Bogucki, David,Yang, Wen,Li, Tongshuang,Wang, Letian,Nan, Susan,Baird, Ian,Metz, Markus,Darkes, Marilyn,Labrecque, Jean,Lau, Gloria,Fricker, Simon,Huskens, Dana,Schols, Dominique
, p. 2450 - 2455 (2011/05/15)
A novel series of CCR5 antagonists were identified based on the redesign of Schering C. An SAR was established based on inhibition of CCR5 (RANTES) binding and these compounds exhibited potent inhibition of R5 HIV-1 replication in peripheral blood mononuclear cells.
