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Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4,5-Dichloro-2-hydroxypyridine is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of novel drugs and pesticides. Its unique structure allows for the creation of a wide range of chemical entities with potential therapeutic and pesticidal properties.
Used in Organic Synthesis:
In the laboratory setting, 4,5-Dichloro-2-hydroxypyridine serves as a valuable reagent in organic synthesis, facilitating the production of diverse chemical compounds. Its presence in reactions can lead to the formation of new molecules with specific functionalities and applications.
Used in Antimicrobial and Fungicidal Applications:
4,5-Dichloro-2-hydroxypyridine has been found to exhibit moderate antimicrobial and fungicidal activity, making it a potential candidate for use in applications where control of microbial and fungal growth is necessary, such as in certain medical or agricultural contexts.

InChI:InChI=1/C5H3Cl2NO/c6-3-1-5(9)8-2-4(3)7/h1-2H,(H,8,9)

Upstream product

• 55934-01-5 2,3,5-trichloropyridine 
• 188577-68-6 4,5-dichloro-2-aminopyridine 

Downstream Products

• 103766-25-2 5-Chloro-2,4-dihydroxypyridine 
• 55934-01-5 2,3,5-trichloropyridine 
• 875232-70-5 2,4-dibromo-5-chloropyridine 

Relevant academic research and scientific papers

Preparation method of 4,5-dichloro-2-hydroxypyridine

The invention discloses a preparation method of 4,5-dichloro-2-hydroxypyridine. The method comprises the following steps that S1, chlorine-containing organic matter and 2,4,5-trihydroxy pyridine are added into a reaction bottle in sequence, heating reflux is conducted for 16-48 hours, concentration and extraction are conducted, organic phases are combined, a drying agent is added to the organic phases, filtering and rotary evaporation are conducted, and a solvent is removed for obtaining a 2,4,5-trichloropyridine crude product; S2, the 2,4,5-trichloropyridine crude product is dissolved in a polar solvent, an aqueous NaOH solution is added at 0-25 DEG C, a reaction is conducted for 1-6 hours at 0-25 DEG C, extraction is conducted, organic phases are combined, a drying agent is added to theorganic phases, filtering and rotary evaporation are conducted, and a solvent is removed for obtaining a 4,5-dichloro-2-hydroxypyridine crude product; S3, the 4,5-dichloro-2-hydroxypyridine crude product is subjected to recrystallization for obtaining a 2,4,5-trichloropyridine pure product. According to the preparation method of the 4,5-dichloro-2-hydroxypyridine, the raw materials are easy to obtain, the preparation process and purification steps are simple, and industrialization is conveniently achieved.

3 -AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS

This invention relates to 3-azabicyclo[4.1.0] heptane derivatives (I) and their use as orexin receptor antagonists.