85698-99-3

Upstream product

• 2144-08-3 2,3,4-trihydroxybenzylaldehyde 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 85699-01-0 2-hydroxy-3,4,4'-tri(methoxymethoxy)chalkone 
• 1610523-00-6 7,8-bis(benzyloxy)-3-(4-(7,8-bis(methoxymethoxy)-2-oxo-2Hchromene-3-carbonyl)piperazine-1-carbonyl)-2H-chromen-2-one 
• 1610523-17-5 (S)-N-(1-((7,8-dihydroxy-2-oxo-2H-chromen-3-yl)amino)-1-oxo-3-phenylpropan-2-yl)-7,8-dihydroxy-2-oxo-2H-chromene-3-carboxamide 
• 1610523-16-4 (S)-N-(3-cyclohexyl-1-((7,8-dihydroxy-2-oxo-2H-chromen-3-yl)-amino)-1-oxopropan-2-yl)-7,8-dihydroxy-2-oxo-2H-chromene-3-carboxamide 
• 1610523-15-3 (S)-N-(1-cyclohexyl-2-((7,8-dihydroxy-2-oxo-2H-chromen-3-yl)-amino)-2-oxoethyl)-7,8-dihydroxy-2-oxo-2H-chromene-3-carboxamide 
• 85699-02-1 (E)-3-(2-Methoxy-3,4-bis-methoxymethoxy-phenyl)-1-(4-methoxymethoxy-phenyl)-propenone 
• 58749-23-8 licochalcone B 
• 24006-29-9 3,4-dihydroxy-2-methoxy benzaldehyde 

Relevant academic research and scientific papers

Design and synthesis of 3,3′-biscoumarin-based c-Met inhibitors

A library of biscoumarin-based c-Met inhibitors was synthesized, based on optimization of 3,3′-biscoumarin hit 3, which was identified as a non-ATP competitive inhibitor of c-Met from a diverse library of coumarin derivatives. Among these compounds, 38 and 40 not only showed potent enzyme activities with IC50 values of 107 nM and 30 nM, respectively, but also inhibited c-Met phosphorylation in BaF3/TPR-Met and EBC-1 cells. This journal is the Partner Organisations 2014.

Effects of electron-withdrawing substituents on DPPH radical scavenging reactions of protocatechuic acid and its analogues in alcoholic solvents

The DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity of protocatechuic acid (3,4-dihydroxybenzoic acid) and its related catechols was examined. Compounds possessing strong electron-withdrawing substituents showed high activity. NMR analysis of the reaction mixtures of catechols and DPPH radical in methanol showed the formation of methanol adducts. The results suggest that high radical scavenging activity of catechols in alcohol is due to a nucleophilic addition of an alcohol molecule on o-quinones, which leads to a regeneration of a catechol structure. Furthermore, the radical scavenging activity in alcohols would largely depend on the electron-withdrawing/donating substituents, since they affect the susceptibility toward nucleophilic attacks on o-quinone.

Synthesis of 3,4,4'-Trihydroxy-2-methoxychalkone (Licochalkone-B)

Licochalkone-B has been synthesised starting from pyrogallol aldehyde (I) which is partially methoxymethylated and condensed with p-methoxymethoxyacetophenone (III) under alkaline conditions.The resulting chalkone (IV) on methylation followed by demethoxy