857035-29-1

Basic information

• Product Name: 2-CHLORO-3H-BENZIMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2-CHLORO-3H-BENZIMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;ethyl 2-chloro-1H-benzo[d]iMidazole-6-carboxylate;2-Chloro-1H-benzimidazole-6-carboxylic acid ethyl ester
• CAS NO: 857035-29-1
• Molecular Formula: C₁₀H₉ClN₂O₂
• Molecular Weight: 224.64
• Mol File: 857035-29-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 2-CHLORO-3H-BENZIMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3H-BENZIMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(857035-29-1)
• EPA Substance Registry System: 2-CHLORO-3H-BENZIMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(857035-29-1)

Safety Data

• Hazardous Substances Data: 857035-29-1(Hazardous Substances Data)

Usage

General Description

2-Chloro-3H-benzimidazole-5-carboxylic Acid Ethyl Ester is a chemical compound that comprises an ethyl ester functional group with a benzimidazole ring with chlorine atom at the 2nd position. This chemical is used in various laboratory synthesis and chemical reactions, often as an intermediate or catalyst. Due to its varied and complex structure, it can facilitate or participate in a number of different reactions, aiding in the formation of different desired products. However, care must be taken while handling this chemical due to potential risks associated with exposure, including skin and eye irritation. Its properties and hazards might depend on the specific synthesis pathway and other compounds present.

Upstream product

• 634602-84-9 2-hydroxy-3H-benzoimidazole-5-carboxylic acid ethyl ester 

Downstream Products

• 857070-66-7 (2-chloro-3H-benzoimidazol-5-yl)methanol 
• 1009646-55-2 2-[(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)amino]-3H-benzoimidazole-5-carboxylic acid ethyl ester 
• 1009646-67-6 2-phenethylamino-3H-benzoimidazole-5-carboxylic acid ethyl ester 
• 857070-67-8 [2-(3-morpholin-4-ylpropylamino)-3H-benzoimidazol-5-yl]methanol 
• 857035-30-4 2-(1-benzylpiperidin-4-ylamino)-3H-benzoimidazole-5-carboxylic acid ethyl ester 

Relevant articles and documents

Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole derivatives

Design, syntheses, and structure-activity relationships of a novel class of 2-{3-oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole NPY Y5 receptor antagonists are described. The benzimidazole structures were newly designed based on the urea linkage of our prototype Y5 receptor antagonists (2 and 3). By optimizing substituents on the benzimidazole core part of the lead compound 5a, we were able to develop a potent, orally available, and brain-penetrable Y5 selective antagonist (5k). Crown Copyright

5- OR 6-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION

The present invention concerns 5- or 6-substituted-benzimidazole derivatives having inhibitory activity on the replication of the respiratory syncytial virus and having the formula (I) a prodrug, N-oxide, addition salt, quaternary amine, metal complex or