857076-83-6Relevant academic research and scientific papers
3,4-Disubstituted benzofuran P1′ MMP-13 inhibitors: Optimization of selectivity and reduction of protein binding
Li, Wei,Hu, Yonghan,Li, Jianchang,Thomason, Jennifer R.,DeVincentis, Dianne,Du, Xuemei,Wu, Junjun,Hotchandani, Rajeev,Rush III, Thomas S.,Skotnicki, Jerauld S.,Tam, Steve,Chockalingam, Priya S.,Morris, Elisabeth A.,Levin, Jeremy I.
scheme or table, p. 4546 - 4550 (2010/04/25)
Potent 3,4-disubstituted benzofuran P1′ MMP-13 inhibitors have been prepared. Selectivity over MMP-2 was achieved through a substituent at the C4 position of the benzofuran P1′ moiety of the molecule. By replacing a backbone benzene with a pyridine and va
