857080-28-5

Upstream product

• 857080-27-4 5-ethyl-4-benzyloxy-3-methylbenzofuran-2-carboxylic acid ethyl ester 
• 54337-59-6 3'-ethyl-2',6'-dihydroxyacetophenone 
• 857080-16-1 ethyl (2-acetyl-4-ethyl-3-hydroxyphenoxy)acetate 
• 857080-17-2 ethyl 3-methyl-4-hydroxy-5-ethylbenzofuran-2-carboxylate 

Downstream Products

• 857076-19-8 N-{[4'-({[4-(benzyloxy)-5-ethyl-3-methyl-1-benzofuran-2-yl]carbonyl}amino)-1,1'-biphenyl-4-yl]sulfonyl}-L-valine 
• 938443-61-9 2-{4'-[(4-benzyloxy-5-ethyl-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid tert-butyl ester 

Relevant academic research and scientific papers

Biaryl sulfonamides and methods for using same

The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.

Synthesis and SAR of highly selective MMP-13 inhibitors

The structure-based design and synthesis of a series of novel biphenyl sulfonamide carboxylic acids as potent MMP-13 inhibitors with selectivity over MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-14, Aggrecanase 1, and TACE are described.